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Susceptibility genes in conformational diseases


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/21216

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Title: Susceptibility genes in conformational diseases
Authors: von Otter, Malin
E-mail: malin.vonotter@gu.se
Issue Date: 4-Dec-2009
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry
Parts of work: I. Malin E. Andersson*, Annica Sjölander, Niels Andreasen, Lennart Minthon, Oskar Hansson, Nenad Bogdanovic, Christina Jern, Katarina Jood, Anders Wallin, Kaj Blennow, Henrik Zetterberg. Kinesin gene variability may affect tau phosphorylation in early Alzheimer’s disease. International Journal of Molecular Medicine. 2007, 20: 233-239. *Papers published before July 2009 were published in the name Malin E. Andersson.
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II. Malin E. Andersson*, Madeleine Zetterberg, Gunnar Tasa, Mona Seibt Palmér, Erkki Juronen, Pait Teesalu, Kaj Blennow, Henrik Zetterberg. Variability in the kinesin light chain 1 gene may influence risk of age-related cataract. Molecular Vision. 2007, 13: 993-996. *Papers published before July 2009 were published in the name Malin E. Andersson.
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III. Malin von Otter, Sara Landgren, Staffan Nilsson, Caroline Lundvall, Lennart Minthon, Nenad Bogdanovic, Niels Andreasen, Deborah R. Gustafson, Ingmar Skoog, Anders Wallin, Anna Håkansson, Hans Nissbrandt, Madeleine Zetterberg, Gunnar Tasa, Kaj Blennow, Henrik Zetterberg. Kinesin light chain 1 gene haplotypes in three conformational diseases. Accepted for publication in NeuroMolecular Medicine, Oct 2009.

IV. Malin von Otter§, Sara Landgren§, Staffan Nilsson, Dragana Celojevic, Petra Bergström, Anna Håkansson, Hans Nissbrandt, Marek Drozdzik, Monika Bialecka, Mateusz Kurzawski, Kaj Blennow, Michael Nilsson, Ola Hammarsten, Henrik Zetterberg. Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson’s disease. Submitted manuscript, June 2009. §These authors contributed equally to the work.

V. Malin von Otter, Sara Landgren, Staffan Nilsson, Madeleine Zetterberg, Dragana Celojevic, Petra Bergström, Lennart Minthon, Nenad Bogdanovic, Niels Andreasen, Deborah R. Gustafson, Ingmar Skoog, Anders Wallin, Gunnar Tasa, Kaj Blennow, Michael Nilsson, Ola Hammarsten, Henrik Zetterberg. Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer’s disease and age-related cataract. Submitted manuscript, Sept 2009.
Date of Defence: 2009-11-27
Disputation: Fredagen den 27 november 2009, kl 9.00 i Hörsal Kammaren, SU/Sahlgrenska, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Conformational disease
Alzheimer’s disease
Parkinson’s disease
Cataract
Protein aggregation
Cellular transport
Oxidative stress
Susceptibility genes
SNP
Haplotype
Abstract: Conformational diseases are characterized by protein misfolding and aggregation in the affected tissue. The aim of this thesis was to find genetic support for mechanisms in common for three prevalent confor-mational diseases: Alzheimer’s disease (AD), Parkinson’s disease (PD) and cataract. The influence of genetic variability in candidate genes hypothesized to be involved in protein aggregation was investigated for association with risk of the sporadic forms of AD, PD and cataract. Furthermore,... more
ISBN: 978-91-628-7936-5
URI: http://hdl.handle.net/2077/21216
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses from Sahlgrenska Academy

 

 

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