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Absolute Asymmetric Synthesis


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Title: Absolute Asymmetric Synthesis
Authors: Lennartson, Anders
E-mail: Anle@chem.gu.se
Issue Date: 18-Apr-2011
University: University of Gothenburg. Faculty of Science
Institution: Department of Chemistry ; Institutionen för kemi
Parts of work: Paper I: Resolution of Seven-Coordinate Complexes A. Lennartson, M. Vestergren, M. Håkansson, Chem. Eur. J. 2005, 11, 1757.
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Paper II: Total Spontaneous Resolution of Five-Coordinate Complexes A. Lennartson, M. Håkansson, Angew. Chem. Int. Ed. 2009, 48, 5869.
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Paper III: cis- and trans-Bis(benzoylacetonato)pyridinecopper(II): co-crystallisation of isomers and reversible pyridine loss with retention of crystallinity A. Lennartson, M. Håkansson, S. Jagner, N. J. Chem. 2007, 31, 344.
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Paper IV: Total spontaneous resolution of nine-coordinate complexes A. Lennartson, M. Håkansson, CrystEngComm 2009, 11, 1979.
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Paper V: Non-stochastic homochiral helix crystallization: cryptochirality in control? M. Vestergren, A. Johansson, A. Lennartson, M. Håkansson, Mendeleev Commun. 2004, 258.
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Paper VI: Synthesis and Total Spontaneous Resolution of an Octanuclear Organo(oxo)zinc Complex A. Pettersen, A. Lennartson, M. Håkansson, Organometallics 2009, 28, 3567.
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Paper VII: Dipyridinium dichromate: an achiral compound forming chiral crystals A. Lennartson, M. Håkansson, Acta Cryst. 2009, C65, m182.
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Paper VIII: Facile Synthesis of Well-Defined Sodium Hydridoalkylzincates(II) A. Lennartson, M. Håkansson, S. Jagner, Angew. Chem. Int. Ed. 2007, 46, 6678.
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Paper IX: Concomitant formation of chiral and racemic crystals of a diaryl sulfide A. Lennartson, T. Wiklund, M. Håkansson, CrystEngComm 2007, 9, 856.
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Paper X: Concomitant polymorphism: Crystallising dichloro-bis(2,4-lutidine)-zinc as both chiral and racemic phases A. Lennartson, S. Olsson, J. Sundberg, M. Håkansson, Inorg. Chim. Acta 2009
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Paper XI: A Different Approach to Enantioselective Organic Synthesis: Absolute Asymmetric Synthesis of Organometallic Reagents A. Lennartson, S. Olsson, J. Sundberg, M. Håkansson, Angew. Chem. Int. Ed. 2009, 48, 3137.
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Paper XII: Towards Total Spontaneous Resolution of sec-Butylzinc Complexes A. Lennartson, A. Hedström, M. Håkansson. Submitted.

Paper XIII: Spontaneous Resolution and Carbonation of Chiral Benzyllithium Complexes A. Lennartson, J. Sundberg, T. Wiklund, G. Hilmersson, M. Håkansson. Submitted.
Date of Defence: 2009-10-09
Disputation: Fredagen den 9 oktober 2009 kl 13.15 i sal KC, Kemigården 4, Göteborgs Universitet och Chalmers tekniska högskola.
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: absolute asymmetric synthesis
enantioselective synthesis
spontaneous resolution
organozinc reagents
chirality
optical resolution
conglomerate
organometallic chemistry
coordination chemistry
intermolecular interactions
supramolecular chemistry
Abstract: Absolute asymmetric synthesis is the synthesis of optically active products from achiral or racemic precursors only. This has generally been regarded as impossible and is relevant in the discussion of the origins of biomolecular homochirality. A possible route to absolute asymmetric synthesis involves total spontaneous resolution, which is possible for stereochemically labile substances which crystallise as conglomerates (i.e. the enantiomers crystallise in separate crystals). Using total spo... more
ISBN: 978-91-628-7836-8
URI: http://hdl.handle.net/2077/20785
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för kemi
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet

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