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The Neuroblastoma Genome and Epigenome - Patient Stratification and Identification of Candidate Genes


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Title: The Neuroblastoma Genome and Epigenome - Patient Stratification and Identification of Candidate Genes
Authors: Carén, Helena
E-mail: helena.caren@gu.se
Issue Date: 30-Sep-2009
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Medical Genetics
Parts of work: I. Carén H, Ejeskär K, Fransson S, Sjöberg R-M, Krona C, Hesson L, Latif F, Martinsson T. A cluster of genes located in 1p36 are down-regulated in neuroblastomas with poor prognosis, but not due to CpG island methylation. Mol Cancer. 2005 Mar 1;4(1):10.
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II. Carén H, Fransson S, Ejeskär K, Kogner P, Martinsson T. Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours. Br J Cancer. 2007 Nov 19;97(10):1416-24. Epub 2007 Oct 16.
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III. Carén H, Djos A, Nethander M, Sjöberg R-M, Enström C, Nilsson S, Martinsson T. Identification of epigenetically regulated genes that predict patient outcome in neuroblastoma. 2009, submitted

IV. Carén H, Erichsen J, Enerbäck C, Olsson L, Sjöberg R-M, Abrahamsson J, Kogner P, Martinsson T. High-resolution array copy number analyses for detection of deletion, gain, amplification and copy-neutral LOH in primary neuroblastoma tumors; Four cases of homozygous deletions of the CDKN2A gene. BMC Genomics. 2008 Jul 29;9(1):353.
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V. Carén H, Kryh H, Nethander M, Sjöberg R-M, Nilsson S, Abrahamsson J, Kogner P, Martinsson T. High-risk neuroblastoma without MYCN amplification; Characterization of the 11q deletion tumors reveal a poor prognostic chromosome instability phenotype with later onset. 2009, submitted
Date of Defence: 2009-10-16
Disputation: Fredagen den 16 oktober 2009, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: cancer
neuroblastoma
epigenetics
DNA methylation
microarray
tumor suppressor gene
tumor
embryonal
neural crest
bisulfite sequencing
1p36
11q
MYCN
CASZ1
PIK3CD
PRKCDBP
SCNN1A
TGFBI
DHRS3
KRT19
DUSP23
APITD1
H2AFX
Abstract: Neuroblastoma (NB) is a tumor of the sympathetic nervous system, and the most common extracranial tumor of childhood. The prognosis for high-stage NBs is still poor, with survival rates of about 35%. Side-effects of treatment in these young children can also be severe. It is therefore important to develop better tools for improved patient stratification as well as to identify new targets for therapy. Aims: Using genetic and epigenetic approaches, this thesis aimed to analyze candidate genes wit... more
ISBN: 978-91-628-7826-9
URI: http://hdl.handle.net/2077/20458
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet

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