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Targeted Abeta proteomics - A tool to study the pathogenesis of Alzheimer's disease


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Title: Targeted Abeta proteomics - A tool to study the pathogenesis of Alzheimer's disease
Authors: Portelius, Erik
E-mail: erik.portelius@neuro.gu.se
Issue Date: 4-Sep-2009
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry
Parts of work: I. Portelius, E; Westman-Brinkmalm, A; Zetterberg, H; Blennow, K. Determination of beta-amyloid peptide signatures in cerebrospinal fluid using immunoprecipitation-mass spectrometry. Journal of proteome research. 5, 1010-1016, 2006.
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II. Portelius, E; Zetterberg, H; Andreasson, U; Brinkmalm, G; Andreasen, N; Wallin, A; Westman-Brinkmalm, A; Blennow, K. An Alzheimer’s disease-specific beta-amyloid fragment signature in cerebrospinal fluid. Neuroscience letters. 409, 215-219, 2006
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III. Portelius, E; Tran, A; Andreasson, U; Persson, R; Brinkmalm, G; Zetterberg, H; Blennow, K; Westman-Brinkmalm, A. Characterization of amyloid beta peptides in cerebrospinal fluid by an automated immunoprecipitation procedure followed by mass spectrometry. Journal of proteome research. 6, 4433-4439, 2007
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IV. Portelius, E; Price, E; Brinkmalm, G; Stiteler, M; Olsson, M; Persson, R; Westman-Brinkmalm, A; Zetterberg, H; Simon, AJ; Blennow, K. A novel pathway for amyloid precursor protein processing. Neurobiology of aging. In press, 2009
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V. Portelius, E; Zhang, B; Gustavsson, M; Brinkmalm, G; Westman-Brinkmalm, A; Zetterberg, H; Lee, V; Trojanowski, J; Blennow, K. Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer’s disease. Submitted

VI. Portelius, E; Andreasson, U; Ringman, JM; Buerger, K; Daborg, J; Buchhave, P; Hansson, O; Harmsen, A; Gustavsson, M; Hanse, E; Galasko, D; Hampel, H; Blennow, K; Zetterberg, H. Distinct cerebrospinal fluid amyloid beta peptide signatures in sporadic and PSEN1 A431E-associated familial Alzheimer’s disease. Submitted
Date of Defence: 2009-09-25
Disputation: Fredagen den 25 september 2009, kl. 9:00, föreläsningssal Hjärtats aula på SU/Sahlgrenska, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Alzheimer’s disease
Cerebrospinal fluid
Immunoprecipitation
Mass spectrometry
beta-amyloid
Abstract: Alzheimer’s disease (AD) is an age-related progressive neurodegenerative disorder of the central nervous system. Diagnosis and monitoring of sporadic AD has long depended on clinical examination of individuals with end-stage disease. The accumulation of amyloid-β (Aβ) peptides in specific brain regions is believed to represent the earliest event in the pathogenesis of the disease and there is developing consensus for the use of cerebrospinal fluid (CSF) Aβ as a core biomarker for the mild cognit... more
ISBN: 978-91-628-7833-7
URI: http://hdl.handle.net/2077/20444
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses from Sahlgrenska Academy

 

 

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