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http://hdl.handle.net/2077/20444
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File | Description | Size | Format | |
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gupea_2077_20444_1.pdf | Thesis frame | 3126Kb | Adobe PDF | ![]() View/Open |
gupea_2077_20444_3.pdf | Abstract | 127Kb | Adobe PDF | ![]() View/Open |
Title: | Targeted Abeta proteomics - A tool to study the pathogenesis of Alzheimer's disease |
Authors: | Portelius, Erik |
E-mail: | erik.portelius@neuro.gu.se |
Issue Date: | 4-Sep-2009 |
University: | University of Gothenburg. Sahlgrenska Academy |
Institution: | Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry |
Parts of work: | I. Portelius, E; Westman-Brinkmalm, A; Zetterberg, H; Blennow, K. Determination of beta-amyloid peptide signatures in cerebrospinal fluid using immunoprecipitation-mass spectrometry. Journal of proteome research. 5, 1010-1016, 2006. VIEW ARTICLE II. Portelius, E; Zetterberg, H; Andreasson, U; Brinkmalm, G; Andreasen, N; Wallin, A; Westman-Brinkmalm, A; Blennow, K. An Alzheimer’s disease-specific beta-amyloid fragment signature in cerebrospinal fluid. Neuroscience letters. 409, 215-219, 2006 VIEW ARTICLE III. Portelius, E; Tran, A; Andreasson, U; Persson, R; Brinkmalm, G; Zetterberg, H; Blennow, K; Westman-Brinkmalm, A. Characterization of amyloid beta peptides in cerebrospinal fluid by an automated immunoprecipitation procedure followed by mass spectrometry. Journal of proteome research. 6, 4433-4439, 2007 VIEW ARTICLE IV. Portelius, E; Price, E; Brinkmalm, G; Stiteler, M; Olsson, M; Persson, R; Westman-Brinkmalm, A; Zetterberg, H; Simon, AJ; Blennow, K. A novel pathway for amyloid precursor protein processing. Neurobiology of aging. In press, 2009 VIEW ARTICLE V. Portelius, E; Zhang, B; Gustavsson, M; Brinkmalm, G; Westman-Brinkmalm, A; Zetterberg, H; Lee, V; Trojanowski, J; Blennow, K. Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer’s disease. Submitted VI. Portelius, E; Andreasson, U; Ringman, JM; Buerger, K; Daborg, J; Buchhave, P; Hansson, O; Harmsen, A; Gustavsson, M; Hanse, E; Galasko, D; Hampel, H; Blennow, K; Zetterberg, H. Distinct cerebrospinal fluid amyloid beta peptide signatures in sporadic and PSEN1 A431E-associated familial Alzheimer’s disease. Submitted |
Date of Defence: | 2009-09-25 |
Disputation: | Fredagen den 25 september 2009, kl. 9:00, föreläsningssal Hjärtats aula på SU/Sahlgrenska, Göteborg |
Degree: | Doctor of Philosophy (Medicine) |
Publication type: | Doctoral thesis |
Keywords: | Alzheimer’s disease Cerebrospinal fluid Immunoprecipitation Mass spectrometry beta-amyloid |
Abstract: | Alzheimer’s disease (AD) is an age-related progressive neurodegenerative disorder of the central nervous system. Diagnosis and monitoring of sporadic AD has long depended on clinical examination of individuals with end-stage disease. The accumulation of amyloid-β (Aβ) peptides in specific brain regions is believed to represent the earliest event in the pathogenesis of the disease and there is developing consensus for the use of cerebrospinal fluid (CSF) Aβ as a core biomarker for the mild cognit... more |
ISBN: | 978-91-628-7833-7 |
URI: | http://hdl.handle.net/2077/20444 |
Appears in Collections: | Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet Doctoral Theses from Sahlgrenska Academy |