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Clinical and genetical aspects of Celiac Disease


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Title: Clinical and genetical aspects of Celiac Disease
Authors: Gudjónsdóttir, Audur Heida
E-mail: audur.gudjonsdottir@vgregion.se
Issue Date: 2008
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clincial Sciences. Department of Pediatrics
Parts of work: I. Gudjónsdóttir AH, Nilsson S, Ek J, Kristiansson B, Ascher H. The risk of celiac disease in 107 families with at least two aff ected siblings. J Pediatr Gastroenterol Nutr 2004;38:338-42.
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II. Naluai AT, Nilsson S, Gudjónsdóttir AH, Louka AS, Ascher H, Ek J, Hallberg B, Samuelsson L, Kristiansson B, Martinsson T,Nerman O, Sollid LM, Wahlström J. Genome-wide linkage analysis of Scandinavian affected sib-pairs supports presence of susceptibility loci for CD on chromosomes 5 and 11. Eur J Hum Genet 2001;9:938-44.
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III. Gudjónsdóttir AH, Nilsson S, Naluai ÅT, Ek J, Amundsen SS, Wahlström J, Ascher H. Association between genotypes and phenotypes in CD. In press J Pediatr Gastroenterol Nutr 2008.

IV. Gudjónsdóttir AH, Nilsson S, Hugot J-P, Mustalahti K, Clot F, Coto I, Percopo S, Ascher A. Clinical features of DQ2-negative compared to DQ2-positive celiac disease. In manuscript.
Disputation: Torsdagen den 12 juni 2008, kl 13.00, i föreläsningssal 1, Drottning Silvias barn- och ungdomssjukhus, SU/Östra
Date of Defence: 2008-06-12
Disputation: Torsdagen den 12 juni 2008, kl. 13.00, Föreläsningssal 1, Drottning Silvias Barn och Ungdomskliniken SU/Östra, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: celiac disease
sib-pair
screening
genome-wide scan
linkage analysis
heritability
genotypes
DQ2-negative
phenotypes
autoimmune disease
Abstract: Celiac disease (CD), or gluten-sensitive enteropathy, is one of the most common chronic diseases in childhood but is diagnosed in all ages. CD is a genetically driven immunological intolerance to dietary gluten. Th e treatment is a gluten-free diet. Th e diagnostic criteria are the ESPGHAN criteria, which include the histological characteristics of villous atrophy, crypt hyperplasia and increased number of intraepithelial lymphocytes (IEL). Th e clinical manifestations in CD range from seve... more
ISBN: 978-91-628-7484-1
URI: http://hdl.handle.net/2077/20307
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses from Sahlgrenska Academy

 

 

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