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Regulation of innate and adaptive immune responses by Gram-positive and Gram-negative bacteria


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Title: Regulation of innate and adaptive immune responses by Gram-positive and Gram-negative bacteria
Authors: Martner, Anna
E-mail: anna.martner@microbio.gu.se
Issue Date: 20-May-2009
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Infectious Medicine
Parts of work: I.Cecilia Barkman, Anna Martner, Christina Hessle and Agnes E. Wold. 2008. Soluble bacterial constituents down-regulate secretion of IL-12 in response to intact Gram-positive bacteria. Microbes and infection 10:1484-93.
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II. Anna Martner, Susann Skovbjerg, James C . Paton, Agnes E. Wold. Autolysis of Streptococcus pneumoniae prevents phagocytosis and production of phagocyte activating cytokines. Submitted.

III. Anna Martner, Claes Dahlgren, James C. Paton and Agnes E. Wold. 2008. Pneumolysin released during Streptococcus pneumoniae autolysis is a potent activator of intracellular oxygen radical production in neutrophils. Infection and immunity 76:4079-4087.
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IV.Anna Martner, Sofia Östman, Samuel Lundin, Lars Axelsson and Agnes E. Wold. Gram-negative bacteria are superior CD4+ T cell activators compared to Gram-positive bacteria. In manuscript.
Date of Defence: 2009-06-11
Disputation: Torsdagen den 11 juni 2009, kl. 13.00, Föreläsningssalen (plan 3), Guldhedsgatan 10A, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Gram-positive, Gram-negative bacteria
Streptococcus pneumoniae
IL-12
autolysin
pneumolysin
CD4+ T cells
monocytes/macrophages
dendritic cells
Abstract: Bacteria are classified as Gram-positive or Gram-negative, depending on their cell wall structure. The role of the bacterial cell wall in immune regulation is the focus of the current work. Most Gram-positive bacteria stimulate monocytes to produce large amounts of IL-12. IL-12 induces production of IFN-γ in T cells and NK cells, which, in turn, activates the bactericidal capacity of the phagocyte in synergy/concert with TNF, produced by macrophages. We studied the bacterial structures and s... more
ISBN: 987-91-628-7819-1
URI: http://hdl.handle.net/2077/20049
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet

 

 

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