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Remodelling of extracellular matrix in rectal cancer and preoperative radiotherapy


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/19389

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Title: Remodelling of extracellular matrix in rectal cancer and preoperative radiotherapy
Authors: Angenete, Eva
E-mail: eva.angenete@vgregion.se
Issue Date: 6-Apr-2009
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clincial Sciences. Department of Surgery
Parts of work: I. Matrix metalloproteinases in rectal mucosa, tumour and plasma: response after preoperative irradiation. Angenete E, Langenskiold M, Falk P, Ivarsson ML, Int J Colorectal Dis 2007;22(6):667-74
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II. Transforming growth factor beta-1 in rectal tumour, mucosa and plasma in relation to radiotherapy and clinical outcome in rectal cancer patients. Angenete E, Langenskiold M, Palmgren I, Falk P, Oresland T, Ivarsson ML, Int J Colorectal Dis 2007;22(11):1331-8
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III. uPA and PAI-1 in Rectal Cancer-Relationship to Radiotherapy and Clinical Outcome. Angenete E, Langenskiold M, Palmgren I, Falk P, Oresland T, Ivarsson ML, J Surg Res 2008 Apr 7 (E-pub ahead of print)
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IV. Preoperative radiotherapy and extracellular matrix remodelling in rectal mucosa and tumour. Matrix metalloproteinases and plasminogen components. Angenete E, Öresland T, Falk P, Breimer M, Hultborn R, Ivarsson ML, Submitted for publication
Date of Defence: 2009-04-24
Disputation: Fredagen den 24 april 2009, kl. 13.00, lokal Humlen, Servicehuset, Sahlgrenska Universitetssjukhuset/Östra, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: radiotherapy
rectal cancer
extracellular matrix
MMP-2
PAI-1
uPA
Calprotectin
TGF-beta1
Abstract: BACKGROUND Preoperative radiotherapy reduces local recurrence due to rectal cancer, but increases postoperative morbidity. The aim of this thesis was to study the impact of radiotherapy on extracellular matrix (ECM) remodelling enzymes and growth factors after radiotherapy and also their possible use as surrogate markers for complications. A secondary aim was to explore the use of these enzymes and growth factors as markers for tumour classification and risk predictors of metastases and death o... more
ISBN: 978-91-628-7733-0
URI: http://hdl.handle.net/2077/19389
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses from Sahlgrenska Academy

 

 

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