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Formation of Skin Sensitizers from Fragrance Terpenes via Oxidative Activation Routes. Chemical analysis, Structure Elucidation and Experimental Sensitization Studies


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Title: Formation of Skin Sensitizers from Fragrance Terpenes via Oxidative Activation Routes. Chemical analysis, Structure Elucidation and Experimental Sensitization Studies
Authors: Hagvall, Lina
E-mail: lina.hagvall@chem.gu.se
Issue Date: 8-Jan-2009
University: University of Gothenburg. Faculty of Science
Institution: Department of Chemistry ; Institutionen för kemi
Parts of work: I. Fragrance Compound Geraniol Forms Contact Allergens on Air Exposure. Identification and Quantification of Oxidation Products and Effect on Skin Sensitization. Hagvall, L., Bäcktorp, C., Svensson, S., Nyman, G., Börje, A., Karlberg, A-T. Chem. Res. Toxicol. 2007, 20, 807-814.
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II. Autoxidation of Geranial. Hagvall, L., Börje, A., Karlberg, A-T. Manuscript.

III. Cytochrome P450 Mediated Activation of the Fragrance Compound Geraniol Forms Potent Contact Allergens. Hagvall, L., Baron, J. M., Börje, A., Weidolf, L., Merk, H., Karlberg, A-T. Toxicol. Appl. Pharmacol. 2008, 233, 308-313.
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IV. Autoxidation of Linalyl Acetate, the Main Component of Lavender Oil, Creates Potent Contact Allergens. Sköld, M., Hagvall, L., Karlberg, A-T. Contact Dermatitis. 2008, 58, 9-14.
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V. Lavender Oil Lacks Natural Protection Against Autoxidation, Forming Strong Contact Allergens on Air Exposure. Hagvall, L., Sköld, M., Bråred-Christensson, J., Börje, A., Karlberg, A-T. Contact Dermatitis. 2008, 59, 143-150.
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Date of Defence: 2009-01-30
Disputation: Fredagen den 30 januari 2009, kl. 10.00, Hörsal KB, Kemihuset, Kemigården 4.
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: autoxidation
contact allergy
cytochrome P450
essential oil
fragrance
hydroperoxide
local lymph node assay
metabolism
predictive testing
sensitization
skin
terpene
Abstract: The work presented in this thesis emphasizes the importance of considering oxidative activation in the toxicity assessment of fragrance chemicals. Compounds without contact allergenic properties can be activated either via autoxidation in contact with air or via cutaneous metabolism to reactive products which can cause contact allergy. It is important to prevent sensitization as the immunological memory formed in the development of contact allergy persists throughout life. The investigation of c... more
ISBN: 978-91-628-7638-8
URI: http://hdl.handle.net/2077/18951
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för kemi
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet

 

 

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