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T cell Function in Patients with Dilated Cardiomyopathy

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Title: T cell Function in Patients with Dilated Cardiomyopathy
Authors: Lindberg, Erika
Issue Date: 2-Oct-2008
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Molecular and Clinical Medicine
Parts of work: I. Erika Lindberg, Yvonne Magnusson, Kristjan Karason, Bert Andersson. (2008) Lower levels of the host protective IL-10 in DCM – a feature of autoimmune pathogenesis? Autoimmunity 41(6): 478-83.

II. Erika Lindberg, Bert Andersson, Elisabeth Hultgren Hörnquist, Yvonne Magnusson. Impaired activity of the CD4+IFN-gamma+ T lymphocyte subset in patients with dilated cardiomyopathy. Submitted.

III. Erika Lindberg, Bert Andersson, Robert Eggertsen, Yvonne Magnusson. A functional polymorphism in the IFN-gamma gene is associated with susceptibility to dilated cardiomyopathy. Manuscript.
Date of Defence: 2008-10-17
Disputation: Fredagen den 17 oktober 2008, kl. 9.00, i hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: cardiomyopathy
Abstract: Dilated cardiomyopathy (DCM) is a heart muscle disease characterized by dilatation of one or both ventricles together with decreased systolic function. Its etiology is still largely unknown. However, immunological alterations such as the presence of autoantibodies, elevated cytokines in plasma, and viral genomes in the myocardium have been frequently reported. The aim of this thesis was to examine T cell function in patients with DCM. First, cytokines in plasma were measured. In accordance wi... more
ISBN: 978-91-628-7554-1
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet



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