Sahlgrenska Academy / Sahlgrenska akademin: Recent submissions
Now showing items 1-20 of 2835
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Humoral lmmune Response with Focus of lgG Glycosylation -In murine models
(2024-03-14)The humoral immune system orchestrates a vital defense mechanism through the secretion of antibodies, especially Immunoglobulin G (IgG), which actively targets and neutralizes foreign particles and pathogens. Glycosylation ... -
NK cell recognition of malignant cells - a CRISPR approach to define novel mediators
(2024-03-14)Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system, capable of eliminating malignant cells. Their activity is intricately regulated through a balanced interplay between activating and inhibitory ... -
Quality of life and long-term side effects after anal cancer treatment
(2024-02-28)Anal cancer is a rare type of cancer with approximately two hundred new cases in Sweden per year. Treatment usually consists of a combination of radiotherapy and chemotherapy. Overall prognosis is good but about 10% of ... -
Health conditions, functioning and social outcomes in adults with cerebral palsy
(2024-02-21)Background: A majority of individuals with cerebral palsy (CP) are adults, and yet healthcare and research are focused on children. In comparison to the consequences in childhood, little is known about the long-term ... -
A treatment seeking population with Gambling Disorder - Internet treatment, severity and gender
(2024-02-21)Gambling is a common pastime all over the world, but can become harmful in excess and can even develop into an addictive behavior, a Gambling Disorder (GD). The aim of this thesis was to contribute to the clinical understanding ... -
Regulation of amyloid beta generation and its involvement in synaptic function: studies in human iPSC-derived cortical neurons
(2024-02-21)Alzheimer’s disease (AD) is a neurodegenerative disease that affects millions of individuals worldwide and exerts a profound societal and economic impact. Clinically characterized by a gradual loss of memory, cognitive and ... -
Labile glutamate synaptic transmission onto CA1 hippocampal pyramidal neurons: regional, functional and developmental diversity
(2024-02-14)A single neuron in the brain receives tens of thousands of glutamate synapses from other neurons, and these synapses can differ in their properties depending on their role in the neural circuit, during brain development ... -
Outcome after treatment of cerebral aneurysms
(2024-02-08)A cerebral aneurysm is a saccular or tubular-like deformity of the arterial vessel wall which is usually thinner. The rupture of a cerebral aneurysm is associated with a high morbidity and mortality by causing an aneurysmal ... -
Trends and determinants for graft survival among kidney transplanted patients in Sweden
(2024-02-07)According to literature, even after a successful kidney transplantation approximately 50% of the patients risk losing the transplant within ≈15 years. A return to dialysis or a new transplantation is then necessary. ... -
Speech production and literacy in students with intellectual disabilities and communication difficulties
(2024-02-07)Many individuals with intellectual disabilities have difficulties with spoken communication and literacy learning leading to vulnerability. It has been suggested that interventions to promote reading in this group not only ... -
Multiomic profiling of leukemic stem cells in myeloid leukemia: implications for immunotherapy
(2024-02-07)Despite the extensive array of therapies available for treating hematological malignancies, a major challenge in hemato-oncology lies in therapy resistance, which primarily is caused by residual resistant leukemic stem ... -
Melanoma surgery in the era of modern immunotherapy
(2024-01-30)Recent advances in immuno-oncology have led to a paradigm shift in the treatment of advanced cutaneous melanoma. The aim of this thesis is to investigate the role of surgery in the management of melanoma in this modern era ... -
Understanding the role of the Parkinson’s associated kinase LRRK2 in inflammation and infection
(2024-01-16)The innate immune system, which mediates pathogen clearance and tissue healing, requires tight regulation to avert self-destruction. The endo-lysosomal system is best known as a network of vesicles that targets particles ... -
Endodontic inflammatory disease and myocardial infarction
(2024-01-15)Atherosclerosis is the underlying cause to suffering an acute myocardial infarction. Disruption of atherosclerotic plaques lead to thrombus formation and occlusion of the coronary arteries which impedes blood supply to the ... -
Psychosocial Aspects of Dravet Syndrome
(2024-01-15)Dravet syndrome (DS) is a developmental and epileptic encephalopathy, associated with significant neurodevelopmental comorbidity. The aims of this population-based study were to describe the epidemiology, genetics, mortality, ... -
Pregnancy-related pelvic girdle pain management. Tailored physiotherapy treatment strategies anchored in women's experiences and expectations
(2024-01-11)Introduction: Pregnancy-related pelvic pain (PGP) affects over half of all pregnant women. This pain can significantly impact daily activities and limit the ability to move freely, leading to reduced physical activity, ... -
Parathyroid Hormone Hyper- and Hypoparathyroidism Effect of Treatment and Long-term Follow-up Studies
(2024-01-10)Background: High or low parathyroid hormone (PTH) can be challenging in diagnosis and treatment. The prevalence and natural history of normocalcemic hyperparathyroidism (nHPT) are still not known. The knowledge gap regarding ... -
Altering the birthing room - The influence on birth outcomes and provision of care
(2024-01-10)Giving birth is a complex physiological process deeply influenced by psychological and social elements. A prerequisite for optimising this physiological process is to be in an environment that feels safe and protective. ... -
Development of Automated Algorithms for Epicardial Adipose Tissue Analysis in Computed Tomography and their Application in Population Based Research
(2023-12-22)The epicardial adipose tissue (EAT), which surrounds the heart and is separated from other tissues only by the thin layers of the pericardium, has enjoyed intense research for the past decades. Increased inflammatory ... -
Self-reported symptoms and their relation to COVID-19 infection and its severity: A Swedish pilot study
(School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, 2023)On March 11th, 2020, the World Health Organization officially recognized COVID-19 as a global pandemic. Health systems worldwide were overwhelmed, in part due to the variety of new variants that began to emerge, presenting ...