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Perinatal essential fatty acid deficiency in mice: effects on metabolism and behaviour
(2011-05-09)
Maternal nutritional status during pregnancy and lactation influences the health of the adult offspring and an adequate supply of essential fatty acids is important for foetal and postnatal growth and development. The ...
Microarray analysis of gene expression in human adipocytes and adipose tissue
(2008-02-21)
Obesity has reached epidemic proportions worldwide and is associated with several serious conditions such as insulin resistance, type 2 diabetes, hyperlipidemia and atherosclerosis. Adipose tissue exerts important endocrine ...
Molecular mechanisms in obesity-associated metabolic disease
(2007-07-12)
Obesity is associated with increased morbidity and mortality. Subjects with obesity are at risk of developing several serious conditions such as type 2 diabetes, hypertension, coronary heart disease and stroke. This thesis ...
Fatty acids induce potentially atherogenic changes in extracellular matrix proteoglycans
(2007-09-10)
Insulin resistance and type 2 diabetes (T2D) are associated with an increased prevalence of atherosclerotic cardiovascular disease (CVD). A key step in the initiation of atherogenesis is retention of low density lipoproteins ...
Metabolic and ovarian consequences of perinatal sex steroid programming
(2008-11-24)
Endocrine and metabolic disturbances in adulthood may stem from insults such as nutritional and hormonal alterations that occur at critical periods in pre- or postnatal life – a process known as programming. This means ...
Studies on microcirculation in insulin resistance
(2015-11-26)
The overall aim of this thesis was to investigate the microcirculation in insulin resistance, with focus on the expression of endothelin-1, through a translational approach.
Specific aims: 1) Investigate if circulating ...
Foxf2 and Foxc2, two transcription factors that regulate adipocyte metabolism
(2010-05-28)
Type 2 diabetes is the most common metabolic disorder today and has reached epidemic proportions in many countries. Diet-induced insulin resistance plays a central role in the development of type 2 diabetes. Studies included ...
The Role of Gut Dysfunction and Nutritional Factors in Liver Cirrhosis
(2007-03-14)
Malnutrition is a common finding in patients with liver cirrhosis. Malnutrition has been
shown to be associated with increased morbidity and mortality. Its pathogenesis remains
unclear but both poor dietary intake and ...
The susceptibility to metabolic and proliferative diseases - from genetic predisposition to treatment
(2014-05-05)
Obesity and type 2 diabetes increase the risk of cardiovascular disease. Insulin resistance is highly correlated to type 2 diabetes and both obesity and insulin resistance are risk factors for cancer. Bariatric surgery is ...
Polycystic ovary syndrome - Studies of metabolic and ovarian disturbances and effects of physical exercise and electro-acupuncture
(2010-01-15)
Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in premenopausal women. The syndrome is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian (PCO) morphology. Metabolic ...