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Cadherin mediated adhesion and barrier function in the thyroid epithelium


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Title: Cadherin mediated adhesion and barrier function in the thyroid epithelium
Authors: Husmark, Johanna 1970-
Issue Date: 1999
University: Göteborgs universitet/University of Gothenburg
Institution: Institute of Anatomy and Cell Biology
Institutionen för anatomi och cellbiologi
Date of Defence: 1999-12-14
Publication type: Doctoral thesis
Keywords: Thyroid
Primary culture
TSH
IL-1
tight junction
adherens junction
E-cadherin
N-cadherin
cadherin switch
thyroid carcinoma
Abstract: The thyroid gland is mainly composed of epithelial cells (thyrocytes) organized as follicles. The cells are connected by junction complexes that link them together into a cohesive simple epithelium. The junctions are also important for the establishment of a semipermeable barrier that restricts the paracellular flow of ions and other solutes. In the first part of this thesis, the effects of thyroid stimulating hormone (TSH) and pro-inflammatory cytokines on the epithelial barrier of primary cult... more
URI: http://hdl.handle.net/2077/11785
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet

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