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N-linked glycosylation of HIV-1 and Hantaan virus glycoproteins. Implications for vaccination and therapy
(2006)
Enveloped viruses have a great advantage comparedto the non-enveloped viruses due to theirability to acquire not only a host membrane butalso host-specific glycosylation of their surfaceglycoproteins. These carbohydrate ...
Gene expression studies in human astrocytoma, with emphasis on oncostatin M induced effects
(2006)
Brain tumors comprise about one percent of all cancers and astrocytoma is the most common primary brain malignancy. According to the World Health Organization system, the astrocytomas are divided into four grades according ...
Immunoregulation by mononuclear phagocytes. Mechanisms and clinical implications
(2006)
The cytotoxic effector lymphocytes of the immune system, the natural killer (NK) cells and the CD8+ T lymphocytes (CTL), have been ascribed a pivotal role in defense against malignancy. However, the function of these cells ...
Functional genetics of the interleukin-4 receptors in allergic asthma
(2006)
Asthma is a complex disorder, with both genetic and environmental factors contributing to disease development. Our aim was to analyse possible associations between genetic variations of immunologically important genes and ...
Characterization of Camplyobacter jejuni and C. coli from Swedish patients and chickens - antibiotic resistance, genomic diversity and detection
(2006)
Campylobacter jejuni is a Gram-negative, non-spore forming bacterium, which is currently the most common pathogen causing reported cases of food poisoning in Sweden, as well as in most other industrialized countries. Eating ...
On the natural history, diagnosis and treatment of benign prostatic hyperplasia
(2006)
There are a number of important issues which remain unknown or poorly understood in the natural history of benign prostatic hyperplasia (BPH). The standard investigation of patients with BPH gives controversial results in ...
The mechanism of integrin inactivation and cell signalling induced by c-erbB2, an oncogenic growth factor receptor
(2006)
Overexpression of the oncogenic growth factor receptor, c-erbB2, is linked with poor prognosis in breast carcinomas and is used as a target for therapeutic strategies. To elucidate the mechanism underlying the tumorigenic ...
Automated interpretation of gated-SPECT. A new approach to integrate the analysis of left ventricular perfusion and function
(2006)
The general aim of the thesis was to develop and validate an automated decision support system for the interpretation of gated-SPECT myocardial perfusion images. Myocardial perfusion scintigraphy is a widely used method ...
Prognostic and predictive factors in laryngeal cancer treated with radiotherapy
(2006)
Radiotherapy (RT) and surgery are the only two curative treatments for patients with laryngeal cancer (LC). RT has the advantage that it offers a possibility to preserve a functioning larynx and hence a functioning normal ...