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Experimental studies of the regulations of synthesis and release of tissue-type plasminogen activator from vascular endothelium
(2000)
The fibrinolytic system has several important functions and one crucial function is the prevention and removal of fibrin deposits in blood vessels. Tissue-type plasminogen activator (t-PA) plays a key role in this process, ...
On the Regulation of the Serine Protease t-PA and its Inhibitor PAI-1 in the Brain
(2010-09-28)
The serine protease tissue-type plasminogen activator (t-PA) is the main fibrinolytic enzyme in the vascular system, and thus plays a critical role in the dissolution of thrombi. In recent years, researchers have focused ...
On the Tissue-type Plasminogen Activator (t-PA) -7,351C>T Enhancer Polymorphism. Importance for endothelial t-PA gene expression and arterial thrombotic disease
(2004)
Local endothelial release of tissue-type plasminogen activator (t-PA) is an important thromboprotective mechanism. Earlier work by our group has identified a common single nucleotide polymorphism (SNP) at the t-PA locus ...