Browsing by Subject "K-RAS"
Now showing items 1-2 of 2
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Defining RCE1 and ICMT as Therapeutic Targets in K-RAS-induced Cancer
(2009-04-09)CAAX proteins, such as the RAS and RHO proteins, are recognized by a specific CAAX motif at the carboxyl terminus, which undergoes posttranslational modifications. First, a lipid group is attached to the cysteine (the “C”) ... -
The Importance of Isoprenylation and Nf1 Deficiency in K-RAS-induced Cancer
(2009-11-10)The RAS and RHO family proteins contribute to tumorigenesis and metastasis and belong to a family of so called CAAX proteins. The membrane targeting and proper function of CAAX proteins are dependent on posttranslational ...