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oai:gupea.ub.gu.se:2077/415442016-02-11T02:31:24Zcom_2077_282com_2077_17com_2077_10556col_2077_544col_2077_310col_2077_10557

Barnevik Olsson, Martina 2016-02-10T12:52:04Z 2016-02-10T12:52:04Z 2016-02-10 978-91-628-9712-3 (PRINT) 978-91-628-9713-0 (PDF) http://hdl.handle.net/2077/41544 Background: Studies of early indicators, diagnostic stability and outcome at mid-school age in children referred early in life for a suspected autism spectrum disorder (asd) have been few. Aims: To examine early indicators of asd and eight-year stability of asd diagnoses, comorbidity, cognitive levels and overall clinical profiles, in children diagnosed with asd in preschool age after receiving early intervention. Methods: A community-based cohort of 208 preschool children with asd were followed prospectively. Records from Child Healthcare Centers were reviewed regarding regulatory problems (rp) during infancy. When the children were about 11 years, parents of 128 of the children participated in the Autism-Tics, ad/hd and other Comorbidities (a-tac) Telephone Interview. A subgroup of 50 children with asd who had had borderline intellectual functioning (bif) – were targeted for a new cognitive test. Another subgroup of 17 children who had “grown out of autism” (i.e. had no longer met diagnostic criteria for asd at a previous follow-up) were separately targeted for followup. Parental telephone interviews in these subgroups also included the Vineland Adaptive Behavior Scales and a semi-structured interview regarding the child’s daily functioning. Results: Early rp had been significantly more common in children later diagnosed with asd. Approximately 90% of children with an early diagnosis of asd still met criteria for asd at midschool age. A similar rate also had combinations of other developmental/neuropsychiatric disorders; attention problems, speech-/language diiculties and/or learning problems. Co-occurring disorders were particularly prevalent in children with asd and intellectual disability. Half of the children in the group still met criteria for bif, 20% had mild id (intellectual disorder), while 30% had cognitive results in the average iq range. The vast majority of the children who had “grown out of autism” still had major problems at follow-up, and some of them had indications of again meeting full criteria for a diagnosis of asd. Conclusion: Early rp should be considered a possible marker for asd. Almost all children with a preschool diagnosis of asd had remaining neurodevelopmental problems eight years later, findings that support the concepts of essence (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations) and Autism Plus. The results underscore the need for follow-up assessments, educational adaptations and longer-term parental support targeted to this patient group. eng I. Barnevik Olsson M et al. Autism before diagnosis: crying, feeding and sleeping problems in the first two years of life. Acta Paediatrica 2013;102:635–39 ::doi::10.1111/apa.12229 II. Barnevik Olsson M, Lundström S, Westerlund J, Giacobini MB, Gillberg C, Fernell E. Preschool to school in autism: neuropsychiatric problems 8 years after diagnosis at 3 years of age. Manuscript III. Barnevik Olsson M, Holm A, Westerlund J, Hedvall Å, Gillberg C, Fernell E. Children with Autism Spectrum Disorder of below average IQ: developmental trajectories from 3 to 11 years of age. Submitted IV. Barnevik Olsson M et al. ”Recovery” from the diagnosis of autism – and then? Neuropsychiatric Disease and Treatment 2015;11:999-1005 ::doi::10.2147/NDT.S78707 Autism spectrum disorder autistic traits neurodevelopmental disorders attention-deficit/hyperactivity disorder language impairment regulatory problems A-TAC adaptive behavior borderline intellectual functioning intellectual disability outcome ESSENCE Autism Plus Autism spectrum disorders - first indicators and school age outcome text Doctoral thesis Doctor of Philosophy (Medicine) martina.barnevik.olsson@gnc.gu.se University of Gothenburg. Sahlgrenska Academy Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry Fredagen den 18 mars 2016, kl 13:00, Hörsal Arvid Carlsson, Medicinaregatan 3, Göteborg 2016-03-18 SA open.access