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oai:gupea.ub.gu.se:2077/336572013-09-06T01:30:12Zcom_2077_29047com_2077_4716com_2077_10556col_2077_29054col_2077_10557

Mattsson, Cecilia 2013-09-05T07:59:53Z 2013-09-05T07:59:53Z 2013-09-05 978-91-628-8741-4 http://hdl.handle.net/2077/33657 It is known since the 1950s that enhancement of the levels of the monoamines dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) in the brain will relieve the symptoms of major depression, and current therapies are still based on this mechanism. However, all available antidepressants today are still suffering from slow onset of therapeutic action, as well as adverse effects and lack of efficacy. Therefore, development of compounds with new mechanisms of action for treatment of depression is needed. One of the most important stages of the drug discovery process is the generation of lead compounds. Structure-activity relationships (SARs) are well integrated in modern drug discovery and have been used in the process of developing new leads. The tetrahydropyridine/piperidine indoles are known to affect multiple targets of the dopaminergic and serotonergic systems in the brain. This class of indoles can easily be modified and they possess the necessary properties for a lead, such as low molecular weight and high water solubility. This thesis is focused on further exploring the SAR around tetrahydropyridine/piperidine indoles by introduction of substituents and/or bioisosteric replacements of the indole core with the aim of developing novel compounds acting at the dopaminergic and serotonergic systems in the brain. By using in vivo and in vitro screening approaches, 5-HT type 6 receptor (5-HT6) agonists, DA type 2 receptor (DA D2) antagonists, 5-HT reuptake transporters (SERT) inhibitors, dual DA D2 antagonists/SERT inhibitors and finally reversible monoamine oxidase A (MAO A) inhibitors were identified after modifications of the chemical lead. In addition, the SAR of 6-substituted 3-(pyrrolidin-1-ylmethyl)chromen-2-ones (coumarin derivatives) were also investigated and were identified as selective and reversible MAO A inhibitors. Three compounds, i.e. the 5-HT6 agonist 81, the dual DA D2 antagonist/SERT inhibitor 158 and the MAO A inhibitor 134 have been identified to be of potential interest as novel antidepressants. eng I. 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists. Mattsson C, Sonesson C, Sandahl A, Greiner HE, Gassen M, Plaschke J, Leibrock J, Boettcher H. Bioorg Med Chem Lett. 2005, 15, 4230-4234.::PMID::16055331 II. Structure-activity relationship of 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole analogues as 5-HT6 receptor agonists. Mattsson C, Svensson P, Boettcher H, Sonesson C. Eur J Med Chem. 2013, 63, 578-588.::PMID::23542166 III. Systematic in vivo screening of a series of 1-propyl-4-aryl-piperidines against dopaminergic and serotonergic properties in rat brain: a scaffold-jumping approach. Mattsson C, Andreasson T, Waters N, Sonesson C. J Med Chem. 2012, 55, 9735-9750; Correction: J Med Chem. 2013, 56, 4130-4133.::PMID::23043306 IV. A novel series of 6-substituted 3-(pyrrolidin-1-ylmethyl)chromen-2-ones as selective monoamine oxidase (MAO) A inhibitors. Mattsson C, Svensson P, Sonesson C. dopamine D2 receptor serotonin reuptake transporter monoamine oxidase 5-HT6 receptor DOPAC 5-HIAA 3-tetrahydropyridine indole 3-piperidine indole 3-(pyrrolidin-1-ylmethyl)chromen-2-one Development of novel serotonin 5-HT6 and dopamine D2 receptor ligands and MAO A inhibitors - Synthesis, structure-activity relationships and pharmacological characterization Text Doctoral thesis Doctor of Philosophy cecilia.m.mattsson@gmail.com University of Gothenburg. Faculty of Science Department of Chemistry and Molecular Biology ; Institutionen för kemi och molekylärbiologi kl. 09.00 i KA-salen, Kemihuset Chalmers, Institutionen för kemi och molekylärbiologi, Kemigården 4, Göteborg 2013-09-26 MNF open.access