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oai:gupea.ub.gu.se:2077/289652013-04-23T15:14:04Zcom_2077_280com_2077_17com_2077_10556col_2077_545col_2077_310col_2077_10557

Rizell, Sara 2012-05-25T07:55:34Z 2012-05-25T07:55:34Z 2012-05-25 978-91-628-8474-1 0348-6672 http://hdl.handle.net/2077/28965 The overall aim of this thesis was to study dentofacial morphology in Turner syndrome (TS) versus controls and the influence hereupon from karyotype. One hundred thirty two TS females (5-66 years of age), from Göteborg, Uppsala and Umeå were participating. Cephalometric analysis, cast model analysis concerning palatal height, dental arch morphology and dental crown width were performed. Eighteen primary teeth were analysed in polarized light microscopy, scanning electron microscopy, microradiography and X-ray microanalysis were performed. The TS females were divided according to karyotype into: 1 45,X; 2 45,X/46,XX; 3 isochromosome; 4 other. Compared to healthy females, TS were found to have a flattened cranial base as well as small and retrognathic jaws with a posterior inclination. The maxillary dentoalveolar arch was narrower and longer, while the mandibular dental arch was wider and longer in TS compared to controls. The palatal height did not differ comparing TS and healthy females. The dental crown width was smaller in TS for both permanent and primary teeth. Aberrant elemental composition, prism pattern and lower mineral density were found in TS primary enamel compared to enamel in primary teeth from healthy girls. Turner syndrome karyotype was found having an impact on craniofacial morphology, with the mosaic 45,X/46,XX exhibiting a milder mandibular retrognathism as well as fewer cephalometric variables differing from controls compared to other karyotypes. Also for the dentoalveolar arch morphology the 45,X/46,XX group had fewer variables differing from healthy females. The isochromosome TS group exhibited the smallest dental crown width for several teeth, while 45,X/46,XX hade the largest dental crown with for some teeth and fewer teeth than both 45,X and isochromosomes that differed from controls. Thus, the mosaic 45,X/46,XX seemed to exhibit a milder phenotype, possibly due to presence of healthy 46,XX cell lines. eng I. Rizell S, Barrenäs ML, Andlin-Sobocki A, Stecksén-Blicks C, Kjellberg H. 45,X/46,XX karyotype mitigates the aberrant craniofacial morphology in Turner syndrome. Eur J Orthod. 2012 Apr 24. ::PMID::22531663 II. Rizell S, Barrenäs ML, Andlin-Sobocki A, Stecksén-Blicks C, Kjellberg H. Palatal height and dental arch dimensions in Turner syndrome karyotypes. Submitted III. Rizell S, Barrenäs ML, Andlin-Sobocki A, Stecksén-Blicks C, Kjellberg H. Turner syndrome isochromosome karyotype correlates with decreased dental crown width. Eur J Orthod. 2012 Apr;34(2):213-8. ::PMID::21303812 IV. Rizell S, Kjellberg H, Dietz W, Norén JG, Lundgren TAltered inorganic composition of dental enamel and dentin in primary teeth from girls with Turner syndrome. . Eur J Oral Sci. 2010 Apr;118(2):183-90. ::PMID::20487008 orthodontics Turner syndrome genetics karyotype geno-phanotype correlation anthropometrics craniofacial morphology dental arch dental crown width enamel primary teeth elemental composition Dentofacial morphology in Turner Syndrome karyotypes Text Doctoral thesis Doctor of Philosophy (Odontology) sara.rizell@vgregion.se University of Gothenburg. Sahlgrenska Academy Institute of Odontology. Department of Orthodontics Fredagen den 15 juni 2012, kl 9.00, Hörsal Arvid Carlsson, Academicum, Medicinareg 3 2012-06-15 SA open.access