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oai:gupea.ub.gu.se:2077/210792013-04-23T15:08:34Zcom_2077_284com_2077_17com_2077_10556col_2077_305col_2077_310col_2077_10557

Kimber, Eva 2009-10-19T12:09:18Z 2009-10-19T12:09:18Z 2009-10-19T12:09:18Z 978-91-628-7928-0 http://hdl.handle.net/2077/21079 Arthrogryposis Causes, Consequences and Clinical Course in Amyoplasia and Distal Arthrogryposis Background. Arthrogryposis Multiplex Congenita, AMC, is a heterogeneous condition defined as multiple congenital joint contractures in two or more body areas. The pathogenesis is impaired fetal movements. Amyoplasia, the most fre- quent form, is a sporadically occurring condition with hypoplastic muscles and joint contractures. Distal arthrogryposis (DA) syndromes are often hereditary, and joint involvement is predominantly in hands and feet. Arhrogryposis with CNS involvement includes chromosomal and other syndromes. Aims. The purpose of this study was to investigate patients with arthrogrypo- sis, to classify the different occurring forms, and to investigate causes, muscle and joint involvement, motor function, treatment and outcome. Methods. Patients were identified via pediatric rehabilitation centers. Family and case history including perinatal findings were recorded. Physical investiga- tion included joint range of motion, muscle strength and motor function. In patients with DA molecular genetic and, in selected cases, muscle morphologic investigations were carried out. Results. 131 patients with arthrogryposis were investigated. The most frequent diagnoses were amyoplasia and DA. In amyoplasia, community ambulators had the best muscle strength, household ambulators had severe contractures in legs but good muscle strength in arms, and non-ambulators had the most severe contractures and muscle weakness. Muscle strength was found to be more im- portant than joint range of motion for motor function. In DA, muscle weakness was present in 44% of investigated patients. Mutations in sarcomeric muscle protein genes were found in seven families with autosomal dominant and in one child with sporadic DA. In one family with a mutation in TNNI2 there were mild myopathic findings, in one family with mutation in TPM2 no obvious myopathy, and in patients from three families with MYH3 mutations mild myopathic findings. Clinical findings were found to be highly variable between families and also within families with DA. Conclusions. Different forms of arthrogryposis were identified. In amyopla- sia, attention should be directed at development of muscle strength with early stimulation of active movements. Immobilisation should be minimized. DA syndromes are clinically and genetically heterogeneous conditions. Fetal my- opathy due to sarcomeric protein dysfunction can cause DA. An early multi- disciplinary team evaluation for specific diagnosis and planning of treatment is recommended. Key words. Arthrogryposis, amyoplasia, distal arthrogryposis, muscle involve- ment, motor function, contractures, muscle morphology, sarcomeric protein dysfunction. Gothenburg 2009 eng I. Kroksmark AK, Kimber E, Jerre R, Beckung E, Tulinius M: Muscle Involvement and Motor Function in Amyoplasia. Am J Med Genet A 2006;140:1757-67::PMID::16835916 II. Kimber E, Tajsharghi H, Kroksmark AK, Oldfors A, Tulinius M: A mutation in the fast skeletal muscle troponin I gene causes myopathy and distal arthrogryposis. Neurology 2006;67:597-601::PMID::16924011 III. Tajshargi H, Kimber E, Holmgren D, Tulinius M, Oldfors A: Distal arthrogryposis and muscle weakness associated with a beta-tropomyosin mutation. Neurology 2007;68:772-5::PMID:: 17339586 IV. Tajsharghi H, Kimber E, Kroksmark AK, Jerre R, Tulinius M, Oldfors A: Embryonic myosin heavy-chain mutations cause distal arthrogryposis and developmental myopathy that persists postnatally. Arch Neurol 2008;65:1083-90::PMID::18695058 V. Kimber E, Tajsharghi H, Kroksmark AK, Oldfors A, Tulinius M: Distal arthrogryposis: Clinical and genetic findings. Unpublished manuscript arthrogryposis amyoplasia distal arthrogryposis muscle involvement motor function contractures muscle morphology sarcomeric protein dysfunction Arthrogryposis. Causes, Consequences and Clinical Course in Amyoplasia and Distal Arthrogryposis text Doctoral thesis Doctor of Philosophy (Medicine) eva.kimber@bredband.net University of Gothenburg. Sahlgrenska Academy Institute of Clincial Sciences. Department of Pediatrics Fredagen den 6 november 2009, kl.13.00, föreläsningssal 1, Drottning Silvias barn-och ungdomssjukhus, Göteborg 2009-11-06 SA open.access