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Now showing items 11-20 of 40
Synthesis of Novel Inhibitors of IdeS, a Bacterial Cysteine Protease Including Studies of Stereoselective Reductive Aminations
(2011-09-30)
Abstract
The cysteine protease IdeS is an IgG degrading enzyme secreted by the bacterium Streptococcus
pyogenes to evade the human immune system. In this thesis several inhibitors of IdeS have been
synthesized and ...
AQUAPORINS: Production Optimization and Characterization
(2011-05-05)
Aquaporins are water facilitating proteins embedded in the cellular membranes. Such channels have been identified in almost every living organism – including humans. They are vital molecules and their malfunction can lead ...
Isothiocynates as skin sensitizers. Bioactivation and distribution in skin and lymph nodes
(2010-11-05)
Development of contact dermatitis can be caused by electrophilic compounds (haptens) or prohaptens that come into contact with the skin. A prohapten is a compound seemingly harmless at first sight that can be transformed ...
Development and use of optical sensors in modern analytical chemistry
(2010-04-09)
A successful long-term high resolution imaging experiment in marine sediments was performed (17 days within the sample; Paper I). The time correlated calibration procedure was evolved to include parametric sigmoidal and ...
Physical properties and processes of secondary organic aerosol and its constituents
(2011-10-27)
Atmospheric aerosol particles are involved in several important processes including the formation of clouds and precipitation. A considerable fraction of the ambient aerosol mass consists of organic compounds of both primary ...
Formation of Skin Sensitizers from Fragrance Terpenes via Oxidative Activation Routes. Chemical analysis, Structure Elucidation and Experimental Sensitization Studies
(2009-01-08)
The work presented in this thesis emphasizes the importance of considering oxidative activation in the toxicity assessment of fragrance chemicals. Compounds without contact allergenic properties can be activated either via ...
Samarium(II)-mediated reactions in organic synthesis - method development and mechanistic investigation
(2010-04-07)
This thesis describes the development of methods using divalent samarium reagents in organic synthesis. The main focus is placed on functional group reductions, but reductive formation of carbon-carbon bonds has also been ...
Theoretical Investigations of the Role of Ion-Ion Correlations and Ion-Specific Interactions in Electric Double Layers
(2009-09-10)
Electric double layers are ubiquitous, arising in some form in almost every situation involving an interface with an aqueous electrolyte solution. In order to gain insight into the behavior of electrolytes and electric ...
Analysis of phospholipids in cellular membranes with LC and imaging mass spectrometry
(2011-05-20)
Imaging mass spectrometry enables the creation of molecule specific images from the surface of a solid sample in vacuum. To solve the issue of bringing single cells into vacuum without altering their native distribution ...
Hydrolytic Synthesis and Physicochemical Properties of TiO2 Nanoparticles: Fundamentals and Applications
(2012-04-13)
Titanium dioxide (TiO2) nanoparticles were synthesized via the hydrolysis of TiCl4 in order to
produce clean, surfactant-free oxide surfaces. By controlling the synthesis and aging conditions, stable particles with ...