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Isothiocynates as skin sensitizers. Bioactivation and distribution in skin and lymph nodes 

Samuelsson, Kristin (2010-11-05)
Development of contact dermatitis can be caused by electrophilic compounds (haptens) or prohaptens that come into contact with the skin. A prohapten is a compound seemingly harmless at first sight that can be transformed ...
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Electrochemical and Enzymatic In Vitro Studies on Reactive Drug Metabolites Synthesis, Characterization and Avoidance 

Johansson Mali'n, Tove (2010-05-03)
ABSTRACT During development of pharmaceuticals, it is essential to as early as possible identify and preferably avoid formation of reactive metabolites and ...
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Experimental and computational investigation of affinity and selectivity factors in CYP2D6 and CYP3A4 mediated metabolism 

Bonn, Britta (2010-09-02)
The assessment of ADME properties and metabolic behavior of a drug is central in drug discovery and drug design. The main target for studies of metabolic properties is the Cytochrome P450 (CYP), which is responsible for ...

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AuthorBonn, Britta (1)Johansson Mali'n, Tove (1)Samuelsson, Kristin (1)Subject
Cytochrome P450 (3)
Metabolism (2)Allergic contact dermatitis (1)Biotransformation (1)biotransformation (1)computational modeling (1)Covalent binding (1)Diphenylthiourea (1)Drug (1)drug design (1)... View MoreDate Issued2010 (3)Has File(s)Yes (3)

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