Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för kemi by Title
Now showing items 13-32 of 40
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Electrochemical and Enzymatic In Vitro Studies on Reactive Drug Metabolites Synthesis, Characterization and Avoidance
(2010-05-03)ABSTRACT During development of pharmaceuticals, it is essential to as early as possible identify and preferably avoid formation of reactive metabolites and ... -
Experimental and computational investigation of affinity and selectivity factors in CYP2D6 and CYP3A4 mediated metabolism
(2010-09-02)The assessment of ADME properties and metabolic behavior of a drug is central in drug discovery and drug design. The main target for studies of metabolic properties is the Cytochrome P450 (CYP), which is responsible for ... -
Experimental studies of cluster ions containing water, ammonia, pyridine and bisulphate
(2011-10-06)Molecular cluster ions are fascinating subjects of study. Bridging the size gap between molecules and bulk, they often display non-trivial size dependent behaviour and properties. As an example, for some cluster types there ... -
Experimental studies of ice particle formation with tropospheric relevance
(2008-11-07)In their fourth assessment report, the Intergovernmental Panel on Climate Change points out the influence of particles suspended in air, known as an aerosol, as the main uncertainty in the understanding of the climate ... -
Fluxes and transformation of carbon in the Siberian shelf seas under changing environment
(2012-05-16)The Arctic is especially vulnerable to the increased air temperature caused by emissions of greenhouse gases to the atmosphere, carbon dioxide being one of them. In this thesis, both fieldwork and modelling of the East ... -
Formation of Skin Sensitizers from Fragrance Terpenes via Oxidative Activation Routes. Chemical analysis, Structure Elucidation and Experimental Sensitization Studies
(2009-01-08)The work presented in this thesis emphasizes the importance of considering oxidative activation in the toxicity assessment of fragrance chemicals. Compounds without contact allergenic properties can be activated either via ... -
Homochiral Crystals for Selective Synthesis
(2011-04-13)Six new coordination compounds were prepared from monodentate sulfide ligands and copper(I) halides and their crystal structures were determined by single-crystal X-ray diffraction. The aim was to prepare coordination polymers ... -
Hydrolytic Synthesis and Physicochemical Properties of TiO2 Nanoparticles: Fundamentals and Applications
(2012-04-13)Titanium dioxide (TiO2) nanoparticles were synthesized via the hydrolysis of TiCl4 in order to produce clean, surfactant-free oxide surfaces. By controlling the synthesis and aging conditions, stable particles with ... -
Imaging Optodes
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Improving Drug Discovery Decision Making using Machine Learning and Graph Theory in QSAR Modeling
(2010-02-12)During the last decade non-linear machine-learning methods have gained popularity among QSAR modelers. The machine-learning algorithms generate highly accurate models at a cost of increased model complexity where simple ... -
Influence of resuspension on sediment-water solute exchange and particle transport in marine environments
(2011-11-24)Marine sediments contain a large pool of nutrients, which if released would contribute to increased eutrophication, in spite of decreased nutrient loads from land and atmosphere. Resuspension is a process, which might ... -
Integrated biomechanical, electronic and topographic characterization of titanium dental implants
(2011-05-11)Titanium dental implants are medical devices used to restore the function entailed with the loss of one or several teeth. To obtain successful function over long periods, the dental implants must be sufficiently anchored ... -
Isothiocynates as skin sensitizers. Bioactivation and distribution in skin and lymph nodes
(2010-11-05)Development of contact dermatitis can be caused by electrophilic compounds (haptens) or prohaptens that come into contact with the skin. A prohapten is a compound seemingly harmless at first sight that can be transformed ... -
Kemilaborationens bidrag till förståelse - högskolestudentens perspektiv -
(2008-11-14)Den här studien har som mål att försöka förstå hur laborationen bidrar till att underlätta studenternas kognitiva arbete att förstå teorin ingående i deras första kemikurs på akademisk nivå. Empirin har framförallt sökt ... -
Lidar Studies of Tropospheric Aerosols and Clouds
(2008-09-22)An improved description of aerosol and cloud processes is a prerequisite for successful prediction of future climate change. The climate on Earth is controlled by the radiation budget, i.e. the relation between the radiation ... -
Ligand Dependent Regioselectivity in Palladium Mediated Allylic Alkylation
(2010-09-17)In this thesis, different aspects on ligand dependent regioselectivity in palladium mediated allylic alkylation have been studied. It is believed that the regioselectivity is a result of nucleophilic attack trans to ... -
Limonene Hydroperoxides in Allergic Contact Dermatitis. Radical Formation, Sensitizing Capacity and Immunogenic Complex Formation.
(2009-04-24)Contact allergy to fragrance compounds is an increasing problem in the western countries today. R-Limonene is one of the most common fragrance compounds; it is used in hygiene products and cosmetics as well as in industrial ... -
MECHANISTIC INVESTIGATIONS OF TRANSITION METAL CATALYZED REACTIONS
(2011-12-14)Transition metal catalyzed reactions have had a large impact on the human progress for the last century. Several extremely important areas, such as the agricultural industry and the plastic industry, have benefited from ... -
New insights in contact allergy and drug delivery. A study of formulation effects and hapten targets in skin using two-photon fluorescence microscopy
(2011-11-08)The skin is a remarkable barrier, protecting us from invasion of e.g. harmful microorganisms and UV-radiation. However, the skin is not adopted to resist repeated exposure to the multitude of xenobiotics introduced into ... -
On the Electrolyte Induced Aggregation of Concentrated Silica Dispersions - An Experimental Investigation Using the Electrospray Technique
(2011-09-08)Gels are weak, solid-like structures that arise when colloidal particles aggregate to form a network of particle clusters. A variety of colloidal systems that are important scientifically as well as in industrial applications ...