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dc.contributor.authorLabori, Frida
dc.contributor.authorLabori, Frida
dc.date.accessioned2023-01-23T15:29:46Z
dc.date.available2023-01-23T15:29:46Z
dc.date.issued2023-01-23
dc.identifier.isbn978-91-8069-085-0 (print)
dc.identifier.isbn978-91-8069-086-7 (PDF)
dc.identifier.urihttps://hdl.handle.net/2077/74544
dc.description.abstractThe overall aim of this thesis was to investigate two health economic aspects of stroke: (i) the clinical and cost-effectiveness of stroke prevention with left atrial appendage occlusion (LAAO) among persons with atrial fibrillation (AF) and contraindication to OAC, (ii) the long-term consequences of stroke on spouses' healthcare utilisation and financial situation and its potential impact in health economic evaluations. The long-term clinical effectiveness and cost-effectiveness of LAAO among persons with AF and contraindications to OAC were estimated using a systematic review, meta-analysis, and a decision-analytic model. These studies show that LAAO is clinically effective and cost-effective. Further, spouses of persons with stroke healthcare utilisation and financial situation were investigated using a difference-in differences approach. A significant increase in the number of days with inpatient care was identified among spouses. No statistically significant differences were seen among the overall population of spouses' financial situation. However, younger female spouses' income from paid work significantly decreased. In conclusion, LAAO is clinically and cost-effective in a subpopulation of persons with AF that currently can be recommended LAAO in Europe. Further, there is a limited impact on healthcare utilisation and financial consequences in the overall population of spouses of persons with stroke.en
dc.language.isoengen
dc.relation.haspartI. Labori, F., Bonander, C., Persson, J., & Svensson, M. Clinical follow-up of left atrial appendage occlusion in patients with atrial fibrillation ineligible of oral anticoagulation treatment- a systematic review and meta-analysis. Journal of Interventional Cardiac Electrophysiology, 2021, 2:215–225. https://doi.org/10.1007%2Fs10840-021-00953-9en
dc.relation.haspartII. Labori, F., Persson, J., Bonander, C., Jood, K., & Svensson, M. Cost effectiveness analysis of left atrial appendage occlusion in patients with atrial fibrillation and contraindication to oral anticoagulation. European Heart Journal, 2021, 31;43(13): 1348-1356. https://doi.org/10.1093%2Feurheartj%2Fehab847en
dc.relation.haspartIII. Labori, F., Bonander, C., Svensson, M., & Persson, J. Long-term effects on healthcare utilisation among spouses of persons with stroke. Submitted manuscripten
dc.relation.haspartIV. Labori, F., Persson, J., Svensson, M., & Bonander, C. The impact of stroke on spousal and family income: longitudinal evidence from Swedish national registries. Manuscripten
dc.subjectIncomeen
dc.subjectHealthcare utilisationen
dc.subjectInformal careen
dc.subjectLeft atrial appendage occlusionen
dc.subjectSpouseen
dc.subjectStroke preventionen
dc.titleHealth economic aspects of stroke: stroke prevention and effects on spouses' healthcare consumption and incomeen
dc.typetexteng
dc.type.svepDoctoral thesiseng
dc.gup.mailfrida.labori@gu.seen
dc.gup.mailfrida.labori@gu.seen
dc.type.degreeDoctor of Philosophy (Medicine)en
dc.gup.originUniversity of Gothenburg. Sahlgrenska Academyen
dc.gup.departmentInstitute of Medicine. Department of Public Health and Community Medicineen
dc.gup.defenceplaceFredagen den 10 februari 2023, kl. 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborgen
dc.gup.defencedate2023-02-10
dc.gup.dissdb-fakultetSA


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