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Proteostasis beyond chaperones - Auxiliary systems in the management of damaged proteins

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Title: Proteostasis beyond chaperones - Auxiliary systems in the management of damaged proteins
Authors: Josefson, Rebecca
Issue Date: 25-Nov-2021
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Medical Microbiology and Immunology
Parts of work: Hill, S. M., Hao, X., Grönvall, J., Spikings-Nordby, S., Widlund, P. O., Amen, T., Jörhov, A., Josefson, R., Kaganovich, D., Liu, B., & Nyström, T. (2016). Asymmetric Inheritance of Aggregated Proteins and Age Reset in Yeast Are Regulated by Vac17-Dependent Vacuolar Functions. Cell Rep, 16, 1-13.

Josefson, R., Hao, X., Liu, B. & Nyström, T. (manuscript). The GET pathway is a major bottleneck for maintaining proteostasis in Saccharomyces cerevisiae.

Josefson, R., Hill, S. M., Hao, X. & Nyström, T. (manuscript). Vacuole inheritance-independent functions of Vac17 in spatial protein quality control and endocytosis.
Date of Defence: 2021-12-17
Disputation: Fredagen den 17 december 2021, kl. 9.00, Hörsal Carl Kylberg, Medicinaregatan 7B, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: aging
protein quality control
asymmetric inheritance
vesicle trafficking
Abstract: Aging entails loss of functionality and increased risk of death, even for unicellular organisms, such as the yeast Saccharomyces cerevisiae. On a cellular level, aging is accompanied by an accumulation of harmful aging factors, e.g. damaged and aggregated proteins. Environmental stress can also cause a protein to misfold, leading to loss of function and aggregation. Protein misfolding is counteracted by systems of protein quality control. The temporal protein quality control system acts to refol... more
ISBN: 978-91-8009-546-4 (PRINT)
978-91-8009-547-1 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin



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