GUPEA >
Faculty of Science / Naturvetenskapliga fakulteten >
Department of Chemistry and Molecular Biology / Institutionen för kemi och molekylärbiologi (2012-) >
Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi >

A Holistic View on Aquaporins: Production, Structure, Function and Interactions


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/66539

Files in This Item:

File Description SizeFormat
gupea_2077_66539_1.pdfThesis file42282KbAdobe PDF
View/Open
gupea_2077_66539_2.pdfCover of the thesis480KbAdobe PDF
View/Open
gupea_2077_66539_3.pdfSpikblad154KbAdobe PDF
View/Open
Title: A Holistic View on Aquaporins: Production, Structure, Function and Interactions
Authors: Schmitz, Florian
E-mail: countdooky@gmail.com
Issue Date: 21-Oct-2020
University: University of Gothenburg. Faculty of Science
Institution: Department of Chemistry and Molecular Biology ; Institutionen för kemi och molekylärbiologi
Parts of work: 1. Schmitz F, Luthman K, Jarho E, Hedfalk K, Seifert T (2020) Efficient production of pure and catalytically active SIRT2 in Pichia pastoris, Manuscript (not submitted)

2. Zeng J, Schmitz F, Isaksson S, Arbab O, Andersson M, Sundell K, Eriksson L, Swaminathan K, Törnroth-Horsefield S, Hedfalk K (2020) Novel structural mechanism of extracellular gating of aquaporin from the fish climbing perch (Anabas testudineus), Manuscript (not submitted)

3. Wang H, Schoebel S, Schmitz F, Dong H, Hedfalk K (2020) Characterization of aquaporin-driven hydrogen peroxide transport. Biochimica et Biophysica Acta (BBA)-Biomembranes, 1862(2), 183065,
VIEW ARTICLE


4. Wang H, Schoebel S, Schmitz F, Dong H, Hedfalk K (2020) Quantitative analysis of H2O2 transport through purified membrane proteins. MethodsX, 7, 100816,
VIEW ARTICLE


5. Schmitz F*, Glas J*, Neutze R, Hedfalk K (2020) High-throughput screening combining bimolecular fluorescence with flow cytometry reveals constructive membrane protein complex formation, Manuscript (not submitted)
Date of Defence: 2020-11-20
Disputation: Fredagen den 11 november 2020, kl 10.00, Hörsal Carl Kylberg, Medicinaregatan 7.
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: aquaporin
membrane proteins
protein interactions
functional studies
Abstract: Aquaporins are specialised membrane proteins, which regulate the water homeostasis of cells. In eukaryotic organisms, this process is tightly regulated, and aberrations in aquaporin functionality lead to severe pathologies in humans. The aim of this thesis is to shed light on the aquaporin function and regulation, both as individual protein targets and in the cellular context, as well as exploring various applications for human aquaporin 4, specifically. A wide range of biochemical methods have ... more
ISBN: 978-91-8009-068-1
URI: http://hdl.handle.net/2077/66539
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi

 

 

© Göteborgs universitet 2011