Visa enkel post

dc.contributor.authorPåhlman, Magnus
dc.date.accessioned2020-11-13T09:09:06Z
dc.date.available2020-11-13T09:09:06Z
dc.date.issued2020-11-13
dc.identifier.isbn978-91-8009-030-8 (print)
dc.identifier.isbn978-91-8009-031-5 (pdf)
dc.identifier.urihttp://hdl.handle.net/2077/65148
dc.description.abstractBACKGROUND: Autism spectrum disorder (autism) and attention-deficit/hyperactivity disorder (ADHD) are likely underdiagnosed in children with cerebral palsy (CP). Early identification of impairments is important for adequate understanding and support. AIMS: To estimate the prevalence of autism and ADHD in CP in a total population of school-aged children with CP. To describe the associations between autism/ADHD and sex, gestational age, CP type, motor function, intellectual disability (ID), other associated impairments, epilepsy and neuroimaging findings in children with CP. METHODS: A well-defined total population of 264 children with CP from the CP register of western Sweden was examined. All available medical records were scrutinised for diagnosed impairments. Parents to all children were invited to complete a comprehensive questionnaire to detect signs of autism and ADHD. Further, children without full concordance between clinical diagnoses and screening outcome for autism/ADHD were assessed. Results were merged with existing information about already assessed children. Neuroimaging findings were compared in regard to the presence of autism and/or ADHD. RESULTS: One third of the 264 children were already diagnosed with autism and/or ADHD (autism 18%, ADHD 21%). Screening was positive to a much higher extent (autism 35%, ADHD 50%). Further neuropsychiatric assessments revealed additionally 19 children meeting diagnostic criteria for autism and/or ADHD. The group that completed screening and assessment comprised 200 children. In total 90 of these 200 children (45%) were diagnosed with autism and/or ADHD; 15% with autism only, 15% with ADHD only and 15% with both autism and ADHD. ID, present in 51%, was the main predictor of autism and ADHD, while both autism and ADHD were mainly independent of gross motor severity and CP type. Autism and ADHD were common in all neuroimaging patterns. However, autism was more prevalent in children with white matter injury, and ADHD in children having sustained middle cerebral artery infarction. CONCLUSION: Autism and ADHD are very common in children with CP and should be regarded as two main associated impairments in CP. The high prevalence of autism and ADHD emphasises the need to screen and, if indicated, further assess all children with CP for these impairments. Further studies, including neuroimaging, may help us better understand the strong association between CP and autism/ADHD.sv
dc.language.isoengsv
dc.relation.haspartI. Påhlman M, Gillberg C, Himmelmann K. One third of school-aged children with cerebral palsy have neuropsychiatric impairments in a population-based study. Acta Paediatr 2019; 108: 2048-2055. ::doi::10.1111/apa.14844sv
dc.relation.haspartII. Påhlman M, Gillberg C, Wentz E, Himmelmann K. Autism spectrum disorder and attention-deficit/hyperactivity disorder in children with cerebral palsy: results from screening in a population-based group. Eur Child Adolesc Psychiatry 2020 Jan 11. Epub ahead of print. ::doi::10.1007/s00787-020-01471-1sv
dc.relation.haspartIII. Påhlman M, Gillberg C, Himmelmann K. Autism and attention-deficit/hyperactivity disorder in children with cerebral palsy: high prevalence rates in a population-based study. Dev Med Child Neurol 2020 Oct 12. Accepted.sv
dc.relation.haspartIV. Påhlman M, Gillberg C, Himmelmann K. Neuroimaging findings in children with cerebral palsy with autism and/or attention-deficit/hyperactivity disorder: a population-based study. Submitted.sv
dc.subjectcerebral palsysv
dc.subjectautism spectrum disordersv
dc.subjectattention-deficit/hyperactivity disordersv
dc.subjectchildrensv
dc.subjectimpairmentssv
dc.subjectscreeningsv
dc.subjectprevalencesv
dc.subjectneuroimagingsv
dc.titleAutism and ADHD in children with cerebral palsysv
dc.typetexteng
dc.type.svepDoctoral thesiseng
dc.gup.mailmagnus.pahlman@gnc.gu.sesv
dc.type.degreeDoctor of Philosophy (Medicine)sv
dc.gup.originUniversity of Gothenburg. Sahlgrenska Academysv
dc.gup.departmentInstitute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistrysv
dc.gup.defenceplaceFredagen den 4 december 2020, kl 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3. https://gu-se.zoom.us/j/69279850423?pwd=T3RHSlYxZ2RLYSs4UnZYUWRUa2crZz09sv
dc.gup.defencedate2020-12-04
dc.gup.dissdb-fakultetSA


Filer under denna titel

Thumbnail
Thumbnail
Thumbnail

Dokumentet tillhör följande samling(ar)

Visa enkel post