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Structural and Interaction Studies of the Human Protein Survivin.


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/59179

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Title: Structural and Interaction Studies of the Human Protein Survivin.
Authors: Garcia-Bonete, Maria-Jose
E-mail: mj.garcia.bonete@gmail.com
maria-jose.garcia.bonete@gu.se
Issue Date: 14-Mar-2019
University: University of Gothenburg. Faculty of Science
Institution: Department of Chemistry and Molecular Biology ; Institutionen för kemi och molekylärbiologi
Parts of work: G. Katona, M.J. Garcia-Bonete and I. Lundholm. Estimating the difference between structure-factor amplitudes using multivariate Bayesian inference, Acta Cryst. A (2016) A72:406-411
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G. Gravina, C. Wasén, M.J. Garcia-Bonete, M. Turkkila, M.C. Erlandsson, S. Töyrä Silfverswärd, M. Brisslert, R. Pullerits, K.M. Andersson, G. Katona and M.I Bokarewa. Survivin in autoimmune disease, Autoimmunity Reviews (2017) 16:845-855
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M.J. Garcia-Bonete, M. Jensen, C.V. Recktenwald, S. Rocha, V. Stadler, M. Bokarewa and G. Katona. Bayesian Analysis of MicroScale Thermophoresis Data to Quantify Affinity of Protein: Protein Interactions with Human Survivin, Scientific Reports
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M.J. Garcia-Bonete and G. Katona. Bayesian machine learning improves single wavelength anomalous difference phasing. [Manuscript] (2019)
Date of Defence: 2019-04-05
Disputation: Fredagen den 5 april 2019, kl. 09:30, Karl Isaksson, institutionen för kemi och molekylärbiologi, Medicinaregatan16
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: survivin
cell cycle
apoptosis
protein interactions
X-ray crystallography
Bayesian inference
Abstract: Cell division and cell death (apoptosis) are two essential processes to maintain the specific number of cells in all multicellular organisms. In humans, the misregulation of these processes leads to severe diseases, such as cancer, and neurological, inflammatory or autoimmune diseases. Proteins are the most versatile macromolecules in all living organisms and are the orchestra directors of the majority of cellular processes. Their three-dimensional structure and the interaction with other molecu... more
ISBN: 978-91-7833-398-1
978-91-7833-399-8
URI: http://hdl.handle.net/2077/59179
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi

 

 

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