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Structural Insight into the Bacterial Sialic Acid Catabolic Pathway

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gupea_2077_57823_1.pdfRhawnie Carlsson kappan11639KbAdobe PDF
gupea_2077_57823_2.pdfRhawnie Carlsson omslag4066KbAdobe PDF
gupea_2077_57823_3.pdfRhawnie Carlsson spikblad208KbAdobe PDF
Title: Structural Insight into the Bacterial Sialic Acid Catabolic Pathway
Authors: Caing-Carlsson, Rhawnie
Issue Date: 2-Nov-2018
University: University of Gothenburg. Faculty of Science
Institution: Department of Chemistry and Molecular Biology ; Institutionen för kemi och molekylärbiologi
Parts of work: 1. Bairy, S., Gopalan, L. N., Setty, T. G., Srinivasachari, S., Manjunath, L., Kumar, J. P., Sai, G.R., Sucharita, B., Nayak, V., Ghosh, S., Sathyanarayanan, N., Caing-Carlsson, R., Wahlgren, W.Y., Friemann, R., Ramaswamy, S. (2018). Automation aided optimization of cloning, expression and purification of enzymes of the bacterial sialic acid catabolic and sialylation pathways enzymes for structural studies. Microb Biotechnol, 11(2), 420-428.

2. Caing-Carlsson, R., Goyal, P., Sharma, A., Ghosh, S., Setty, T. G., North, R. A., Friemann, R., Ramaswamy, S. (2017). Crystal structure of N-acetylmannosamine kinase from Fusobacterium nucleatum. Acta Crystallogr F Struct Biol Commun, 73(Pt 6), 356-362.

3. Caing-Carlsson, R., Goyal, P., Wahlgren, W.Y., Dunevall, E., Ramaswamy, S, Friemann, R.(2018) Expression, purification and crystallization of a sialic acid tripartite ATP-independent periplasmic (TRAP) transporter. Manuscript

4. Wahlgren, W.Y., Dunevall, E., North, R.A., Paz, A., Scalise, M., Bisignano, P., Bengtsson-Palme, J., Goyal, P., Claesson, E., Caing-Carlsson, R., Andersson, R., Beis, K., Nilsson, U.J., Farewell, A., Pochini, L., Indiveri, C., Dobson, R.C.J., Abramson, J., Ramaswamy, S., Friemann, R. (2018). Substrate-bound outward-open structure of a Na(+)-coupled sialic acid symporter reveals a new Na(+) site.Nat Commun, 9(1), 1753.

Date of Defence: 2018-11-23
Disputation: 13:15 Ivan Ivarsson
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: sialic acid
bacterial catabolic pathway
Abstract: A genetically diverse community of commensal and pathogenic bacteria thrive in the digestive system and urogenital tracts of animals. Many of these bacteria forage sialic acid from mucosal cell surfaces. Bacteria have evolved a system that utilizes host-derived sialic acid either as an alternative food source (catabolic pathway) or for molecular mimicry to evade the host’s immune system (sialylation pathway). Their ability to utilize sialic acid confers a selective advantage by securing an ecolo... more
ISBN: 978-91-7833-226-7, pdf
978-91-7833-225-0, tryckt
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi



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