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Helicobacter spp. – host interaction in the mucus niche

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Title: Helicobacter spp. – host interaction in the mucus niche
Authors: Médea, Padra
Issue Date: 30-Nov-2018
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Medical Biochemistry and Cell Biology
Parts of work: I. BabA dependent binding of Helicobacter pylori to human gastric mucins cause aggregation that inhibits proliferation and is regulated via ArsS. Skoog EC*, Padra M*, Åberg A, Gideonsson P, Obi I, Quintana - Hayashi MP, Arnqvist A, Lindén SK. Sci Rep. 2017. 20;7:40656.* Equal contribution

II. Helicobacter suis binding to carbohydrates on human and porcine gastric mucins and glycolipids occurs via two modes. Padra M, Adamczyk B, Benktander J, Flahou B, Skoog EC, Padra JT, Smet A, Jin C, Ducatelle R, Samuelsson T, Haesebrouck F, Karlsson NG, Teneberg S, Lindén SK. Virulence. 2018. 31;9(1):898-918.

III. Helicobacter suis infection alters glycosylation and decreases the pathogen growth inhibiting effect and binding avidity of gastric mucins. Padra M, Adamczyk B, Flahou B, Erhardsson M, Chahal G, Smet A, Jin C, Thorell A, Ducatelle R, Haesebrouck F, Karlsson NG, Lindén SK. Manuscrip

IV. Carbohydrate-dependent and antimicrobial peptide defense mechanisms against Helicobacter pylori infections. Médea Padra, John Benktander, Karen Ro- binson and Sara K. Lindén. Book chapter in “Current Topics in Microbiology and Immunology (CTMI)” by Springer. Accepted
Date of Defence: 2018-12-21
Disputation: Fredagen den 21 december 2018, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Helicobacter
Abstract: Helicobacter pylori is the most common human gastric pathogen, colonizing half of the world's population. Helicobacter suis colonizes the stomach of 60-95% of pigs at slaughter age and it is the most prevalent non-Helicobacter pylori Helicobacter species found in the human stomach causing severe gastric disorders. The first barrier that gastric pathogens encounter is the mucus layer, of which the main components are highly glycosylated mucin glycoproteins. Mucins carry a high diversity of mucosa... more
ISBN: 9789178332533 (PRINT)
9789178332540 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin



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