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Potential Therapeutic Applications of Novel Bioengineered Tissues and Organs Using Methods of Decellularization and Recellularization


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/56896

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Title: Potential Therapeutic Applications of Novel Bioengineered Tissues and Organs Using Methods of Decellularization and Recellularization
Authors: Kuna, Vijay Kumar
E-mail: vijay.kuna.kumar@gu.se
kvijay.crazy@gmail.com
Issue Date: 4-Sep-2018
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clinical Sciences. Department of Surgery
Parts of work: Kuna, VK, Xu B and Sumitran-Holgersson S. Decellularization and recellularization methodology for Human Saphenous Veins. Journal of Visualized Experiments. 2018; 137, e57803.
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Kuna VK, Padma AM, Håkansson J, Nygren J, Sjöback R, Petronis S and Sumitran-Holgersson S. Significantly accelerated wound healing of full-thickness skin using a novel composite gel of porcine acellular dermal matrix and human peripheral blood cells. Cell Transplantation. 2017; 26(2): 293-307.
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Elebring E, Kuna VK, Kvarnström N and Sumitran-Holgersson S. Cold-perfusion decellularization of whole-organ porcine pancreas supports human fetal pancreatic cell attachment and expression of endocrine and exocrine markers. Journal of Tissue Engineering. 2017; 8: 2041731417738145.
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Kuna VK, Paul S, Xu B, Sjöback R and Sumitran-Holgersson S. Human fetal kidney precursor cells regenerate acellular porcine kidneys via upregulation of key transcription factors involved in kidney development. Manuscript.
Date of Defence: 2018-09-25
Disputation: Tuesday, September 25, 2018, 01.00PM, Hörsal Åke Goransson, Medicinaregatan 11
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Tissue engineering
Decellularization
Recellularization
Saphenous vein
Bioreactor
Wound healing
Skin gel
Pancreas
Kidneys
Ephrins
Human fetal stem cells
Abstract: The transplantation of personalized organs or tissues will benefit patients with various diseases and disorders. Decellularization is a method to generate an acellular, non-immunogenic natural scaffold. The personalized tissue can be generated after recellularization with recipient stem cells and it can be transplanted to recipient without the need for immune suppression. The current thesis focuses on developing decellularization and recellularization strategies for simple tissue (human saphenou... more
ISBN: 978-91-7833-073-7 (PRINT)
978-91-7833-074-4 (PDF)
URI: http://hdl.handle.net/2077/56896
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper

 

 

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