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Biophotonics Targeting Pharmaceutical Challenges


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Title: Biophotonics Targeting Pharmaceutical Challenges
Other Titles: Focusing on photopharmaceutical and antimicrobial delivery studies
Authors: Thomsen, Hanna
E-mail: hanna.thomsen@chem.gu.se
Issue Date: 23-Aug-2018
University: University of Gothenburg. Faculty of Science
Institution: Department of Chemistry and Molecular Biology ; Institutionen för kemi och molekylärbiologi
Parts of work: Confined photo-release of nitric oxide with simultaneous two-photon fluorescence tracking in a cellular system Hanna Thomsen, Nino Marino, Sabrina Conoci, Salvatore Sortino, and Marica B. Ericson. Scientific Reports 8, 9753 (2018).
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Monitoring the Release of a NO Photodonor from Polymer Nanoparticles via Förster Resonance Energy Transfer and Two-photon Fluorescence Imaging Claudia Conte, Aurore Fraix, Hanna Thomsen, Francesca Ungaro, Venera Cardile, Adriana C. E. Graziano, Marica B. Ericson, Fabiana Quaglia and Salvatore Sortino. Journal of Materials Chemistry B 6, 249-256 (2017).
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Nanoporous silica particles intercalate at stratum corneum – targeting transcutaneous drug delivery. Sabrina Valetti, Hanna Thomsen, Jitendra Wankar, Peter Falkman, Ilse Manet, Adam Feiler, Johan Engblom, and Marica B. Ericson To be submitted to ACS Nano (2018)

Delivery of cyclodextrin polymers to bacterial biofilms – An exploratory study using rhodamine labelled cyclodextrins and multiphoton microscopy Hanna Thomsen, Gabor Benkovics, Eva Fenyvesi, Anne Farewell, Milo Malanga, and Marica B. Ericson. International Journal of Pharmaceutics 531(2), 650-657 (2017).
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Increased antibiotic efficacy and noninvasive diagnostic monitoring of biofilms by complexation with FITC—tagged cysteamine-substituted cyclodextrins. Hanna Thomsen, Marco Agnes, Owens Uwangue, Fabrice E. Graf, Konstantina Yannakopoulou, Anne Farewell, and Marica B. Ericson Manuscript (2018)

Spatially confined photoinactivation of bacteria towards novel treatment and mechanistic understanding of biofilm growth Hanna Thomsen, Jeemol James, Anne Farewell, and Marica B. Ericson Proc. SPIE Proc, 10498, 1049825 (2018).
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Exploring photoinactivation of microbial biofilms using laser scanning microscopy and confined 2-photon excitation. Hanna Thomsen, Fabrice Graf, Anne Farwell, and Marica B. Ericson Journal of Biophotonics (2018).
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Date of Defence: 2018-09-14
Disputation: Fredagen den 14 september 2018, kl. 13.00, KB, Kemigården 4
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: Multiphoton microscopy
two photon excitation
fluorescence imaging
nanoparticles
antibiotics
cyclodextrins
drug delivery
super resolution microscopy
microbial biofilms
staphylococcus
photodynamic inactivation
Abstract: The study of the interaction between light and biological matter, called biophotonics, contributes to our understanding of biological systems - from subcellular compartments up to the human organ system. Herein, light is employed as a tool to understand delivery of novel photopharmaceutical and antimicrobial systems to bacteria, cells, and tissue. The first part of this thesis (papers I and II) focuses on production of toxic species via photoactivation of a compound, both in cells and tissue, u... more
ISBN: 978-91-7833-055-3
978-7833-056-0
URI: http://hdl.handle.net/2077/56327
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi

 

 

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