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dc.contributor.authorAlmotairi, Fawaz S.
dc.date.accessioned2018-04-04T07:27:56Z
dc.date.available2018-04-04T07:27:56Z
dc.date.issued2018-04-04
dc.identifier.isbn978-91-629-0469-2 (PDF)
dc.identifier.isbn978-91-629-0468-5 (PRINT)
dc.identifier.urihttp://hdl.handle.net/2077/54962
dc.description.abstractBackground Chiari I malformations (CMIs) are hindbrain anomalies that are characterized by cerebellar tonsillar ectopia. The typical presentation is an occipital headache that worsens with exertion. In this thesis, I focus on the following three atypical presentations of CMI: swallowing difficulty, neuropsychological (NP) dysfunction and acute deterioration. In addition, I address the impact of CMI on patient quali-ty of life (QOL). The preoperative factors that predict cerebrospinal fluid disturb-ance (CSFD) after surgery for CMI have rarely been reported and will be discussed and investigated in this thesis. Patients and methods In the first two studies presented in this thesis (studies I & II), patients were prospectively included over a two-year period. Patients underwent both subjective and objective assessments of swallowing function in Study I and of NP functions and QOL in Study II. The total number of patients included were 11 and 14, re-spectively. All patients were assessed both before and at 3 months after surgery. In the last two studies presented in this thesis (studies III & IV), patients were retrospectively included over two overlapping 10-year periods. The total number of patients included were 52 and 65, respectively. In Study III, I explore the pre-operative radiological factors that indicate a risk of acute deterioration in CMI patients. In Study IV, I investigate preoperative patient characteristics that might determine the risk of postoperative CSFD. Results In Study I, four patients (36%) reported varying degrees of swallowing com-plaints (mean Watson Dysphagia score, 16). In two of these patients, there was substantial penetration of contrast on videofluoroscopy, and in the other two pa-tients, minor disturbances were observed. None of the patients reported remaining symptoms after surgical decompression. In Study II, the majority of included patients demonstrated cognitive func-tions within the normal range. However, their postoperative performance on some of the tested NP assessment tools significantly improved. There was a lower level of satisfaction with QOL both before and after surgery in patients than in healthy subjects In addition, the 5-level Euroqol-5 dimensional questionnaire (EQ-5D-5L) indicated that patient QOL was significantly better after surgery. In Study III, three patients (4.6%) presented with acute deterioration of symp-toms. Additionally, the length and size of the syrinx were higher and it was ex-tended more rostral (above C1 level) in these acute patients than in non-acute patients with CMI. In Study IV, six patients developed CSFD after occipitocervical decompression (OCD) and subsequently underwent cerebrospinal fluid (CSF) diversion proce-dures. All of these patients were females, and they had a mean body mass index (BMI) of 32.3, whereas the mean was 24.3 in patients without CSFD (p=0.0011). There was no difference between the two groups in other examined patient char-acteristics. Conclusion Symptoms of dysphagia are not uncommon in CMI patients. A preoperative NP assessment of adult patients with CMI showed that there was a statistically significant improvement in four of the nine tasks tested after surgery. Further-more, preoperative QOL was poorer in CMI patients than in healthy individuals. Surgery can potentially remedy the causes underlying dysphagia and NP dysfunc-tions, thereby relieving their symptoms. Study III shows that it is important to assess the preoperative size, length and rostral extension of the CMI-associated syrinx because changes in these parame-ters could indicate acute deterioration, and affected CMI patients should be as-signed for early surgical decompression. All patients with postoperative CSFD were female, and their mean BMI was significantly higher than that of patients without this complication. Pseudotumor cerebri must be excluded in this group of patients.sv
dc.language.isoengsv
dc.relation.haspartI. Swallowing dysfunction in adult patients with Chiari I malformation; Fawaz S. Almotairi, Mats Andersson, Olof Andersson, Thomas Skoglund, Magnus Tisell. Submitted.sv
dc.relation.haspartII. Chiari I malformation - neuropsychological functions and quality of life, Fawaz S. Almotairi MD, Per Hellström PhD, Thomas Skoglund MD, PhD, Åsa Lundgren Nilsson PhD, Magnus Tisell MD, PhD, Submitted.sv
dc.relation.haspartIII. Acute deterioration of adults with Chiari I malformation associated with extensive syrinx, Almotairi FS, Magnus Tisell, Submitted.sv
dc.relation.haspartIV. Cerebrospinal Fluid Disturbance In Overweight Women After Occip-itocervical Decompression In Chiari Malformation, Almotairi FS, Magnus Tisell , Acta Neurochirurgica: 2016 Mar; 158(3): 589-94; discussion 594. ::PMID::26743916sv
dc.subjectArnold-Chiari Malformationsv
dc.subjectDeglutition Disorderssv
dc.subjectDeglutitionsv
dc.subjectSurveys and Questionnairessv
dc.subjectDecompressive Craniectomysv
dc.subjectTreatment Outcomesv
dc.subjectCognitive Dysfunctionsv
dc.subjectExecutive Functionsv
dc.subjectPatient Satisfactionsv
dc.subjectPsychological Testssv
dc.subjectSyringomyeliasv
dc.subjectEmergenciessv
dc.subjectPostoperative complicationssv
dc.subjectBody mass indexsv
dc.subjectQuality of Lifesv
dc.subjectHydrocephalussv
dc.titleAdult Chiari I malformation - Clinical presentation and surgical outcomessv
dc.typetexteng
dc.type.svepDoctoral thesiseng
dc.gup.mailneurosurgeon@live.comsv
dc.type.degreeDoctor of Philosophy (Medicine)sv
dc.gup.originUniversity of Gothenburg. Sahlgrenska Academysv
dc.gup.departmentInstitute of Neuroscience and Physiology. Department of Clinical Neuroscience and Rehabilitationsv
dc.gup.defenceplaceMåndagen den 14 Maj 2018, kl 13.00, Hjärtat Aula, Sahlgrenska Universitetssjukhuset, Blå stråket 5, Göteborgsv
dc.gup.defencedate2018-05-14
dc.gup.dissdb-fakultetSA


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