Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi
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Evaluating Virtual Reality and Artificial lntelligence as Emerging Digital Tools for Mental Health Care
(2025-01-16)This thesis evaluates the potential of Virtual Reality (VR) and Artificial Intelligence (AI), specifically Natural Language Processing (NLP) and Large Language Models (LLMs), as emerging tools for mental health care. VR ... -
Drug interactions in healthcare - Knowledge resources and clinical management
(2025-01-14)Background and aim: Many patients are treated with several drugs concomitantly, implying a risk of drug interactions. The clinical consequences of drug interactions depend not only on the drugs, but also on patient ... -
Gravitostat: A Homeostatic Regulator of Body Weight
(2025-01-14)This project focuses on elucidating central and peripheral physiological mechanisms behind load-induced body weight reduction. These pre-clinical works are a continuation of previous studies in obese humans and Diet-Induced ... -
Advancements in the Neuropsychology of Alzheimer's Disease
(2025-01-08)Background: In Alzheimer's disease (AD), the buildup of amyloid-β and hyperphosphorylated tau protein in the brain starts years before clinical symptoms appear. This process then progresses in parallel with cognitive ... -
The role of taurine-related compounds on the effects of ethanol in the rat mesolimbic dopamine system
(2025-01-08)Alcohol use disorder (AUD) is a major contributor to the global burden of disease. The reinforcing properties of alcohol involve enhanced dopamine activity in the nucleus accumbens (nAc), an important part of the mesolimbic ... -
Correlative Chemical Imaging of Amyloid Plaque Pathology in Alzheimer’s Disease
(2024-12-11)The formation of beta-amyloid (Aβ) plaques and neurofibrillary tangles are key pathological hall-marks of Alzheimer’s disease (AD), where amyloid has been identified to precede and even initiate other neurodegenerative ... -
Adult psychiatric outpatients; neuropsychiatric, neuropsychological and neurodevelopmental aspects
(2024-12-05)ABSTRACT Background: Neurodevelopmental disorders - including autism and attention- deficit/hyperactivity (ADHD) - are relatively common in the general population with a total prevalence rate of at least 10%. Most research ... -
Nanoelectrochemical analysis of neurotransmitter release in cell models of Alzheimer's disease
(2024-12-04)Neurotransmitter release and binding to receptors are tightly regulated, and aberrant changes can cause neuropsychiatric and neurodegenerative disorders. Alzheimer's disease (AD) is a complex, age-related neurodegenerative ... -
Diagnostic imaging and functional outcome in patients with diffuse glioma grades 2 and 3. From presentation to the 12-month post-operative follow-up
(2024-12-04)The overall aim of this thesis was to contribute to the improvement of diagnostic imaging and functional outcome practices in adult patients with diffuse glioma grades 2 or 3. At the preoperative stage our studies assessed ... -
Team-based rehabilitation in primary care for patients with musculoskeletal disorders Experiences, effect- and process evaluation
(2024-11-20)Most people will experience musculoskeletal disorders at some point in their lives, ranging from a manageable problem to significant difficulties with mobility, sleeping, performing daily activities, and working. There is ... -
Exploring pain, fatigue and physical activity in adolescents with Hypermobility Spectrum Disorder or hypermobile Ehlers-Danlos Syndrome
(2024-11-19)Adolescents with Hypermobility Spectrum Disorder (HSD) and hypermobile Ehlers–Danlos Syndrome (hEDS) — two overlapping hereditary connective-tissue disorders characterized by joint hypermobility, chronic pain, impaired ... -
Novel biomarkers for parkinsonian disorders
(2024-11-12)Parkinsonian disorders (PS) are a heterogeneous group of neurodegenerative diseases characterised by the presence of parkinsonism. Parkinson’s disease (PD) is the most common PS, characterised by the accumulation of ... -
Endocrine and neural mechanisms in metabolic control
(2024-11-11)The regulation of eating behavior and metabolism is governed by complex inter-actions between central and peripheral signals, with hormones such as oxytocin (OT) and glucagon-like peptide-1 (GLP-1) playing pivotal roles. ... -
The alpha 7 nicotinic acetylcholine receptor in cardiovascular disease
(2024-09-26)The alpha 7 acetylcholine nicotinic receptors (α7nAChRs) are expressed on human leukocytes and regulate inflammation. Consequently, the α7nAChRs are potential pharmacological targets for several inflammatory diseases. ... -
Social and motor coordination: methods development and applications in ESSENCE
(2024-09-24)This thesis aimed to develop and apply methods for evaluating social and motor coordination, domains that often are challenged in individuals with neurodevelopmental/neuropsychiatric disorders (NDDs), also referred within ... -
Survival of patients with glioblastoma - advancements in the past two decades
(2024-09-24)Background: Glioblastoma is the most common and most aggressive form of primary malignant brain tumors in adults. The prognosis is generally poor, with a median survival of around 15-16 months, even with aggressive multimodal ... -
Thoracic Mobility in Cystic Fibrosis Care
(2024-08-19)Introduction: Cystic fibrosis (CF) is an incurable and highly life-limiting hereditary disease. However, due to significant medical advancements over recent decades, life expectancy has risen to close to 50 years. As such, ... -
Physical Activity Before and After Stroke - Examining Stroke lncidence and Outcomes
(2024-05-24)Background: Stroke is a leading cause of death and disability worldwide. A physically active lifestyle may prevent stroke and decrease the consequences of a stroke. Physical activity is also an important component in ... -
Ge de ohörda rösterna upprättelse - framsteg och utmaningar vid involvering av sköra äldre personer i forskning om åldrande och hälsa
(2024-05-16)Introduktion: I Sverige och globalt har vi en demografisk utveckling med en allt större del åldrad befolkning. Forskning om åldrande och hälsa har därför en allt viktigare roll i samhället. Samtidigt är det just nu en ... -
Meningiomas - consequences of incidental detection and novel classification
(2024-05-06)Aim Meningiomas are often benign, slow-growing tumors found in older individuals. This thesis aimed to examine the occurrence of incidental meningioma, the surgical and quality of life outcomes after surgery and to evaluate ...