Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi
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Cholinergic modulation of dopamine-related effects of ethanol in the rat
(2024-04-25)Alcohol use disorder is associated with serious medical consequences leading to preterm death. Alcohol activates the brain reward system, leading to an increase of extracellular dopamine (DA) levels in the nucleus accumbens ... -
Psychological outcomes during rehabilitation after ACL reconstruction - and implications for second ACL injury
(2024-04-24)An anterior cruciate ligament (ACL) injury is a common knee joint injury. An ACL injury is typically managed through surgical reconstruction of the ligament, followed by rehabilitation. For patients treated with ... -
Predictors of severe kidney disease in long-term lithium treatment
(2024-04-22)The thesis aims to advance the understanding of severe chronic kidney disease in lithium-treated patients through four observational studies in which subjects were recruited from the Sahlgrenska University Hospital laboratory ... -
Physiotherapist as primary assessor of knee osteoarthritis in primary care - Evaluation of patients’ self-assessment, preferences, quality of life, and health economy
(2024-03-27)Aim: The purposes with this thesis was to evaluate the feasibility of 30-second chair stand test as a self-test, and to investigate the effects of direct access to physiotherapist on costs and health in people with knee ... -
lnduction Therapies in Multiple Sclerosis - Clinical and immunological follow-up
(2024-03-21)Multiple sclerosis (MS) is a chronic disease that damages the central nervous system. Its pathophysiology is complex, and consists of inflammation and degeneration from the disease onset. The treatment of MS has continuously ... -
Polycystic ovary syndrome in women with severe obesity - effects of a 12-month weight loss intervention
(2024-03-19)Background: Polycystic ovary syndrome (PCOS) affects one out of eight women and is associated with reproductive, metabolic, and psychiatric features. There is a strong association with obesity but studies on PCOS in women ... -
Health conditions, functioning and social outcomes in adults with cerebral palsy
(2024-02-21)Background: A majority of individuals with cerebral palsy (CP) are adults, and yet healthcare and research are focused on children. In comparison to the consequences in childhood, little is known about the long-term ... -
A treatment seeking population with Gambling Disorder - Internet treatment, severity and gender
(2024-02-21)Gambling is a common pastime all over the world, but can become harmful in excess and can even develop into an addictive behavior, a Gambling Disorder (GD). The aim of this thesis was to contribute to the clinical understanding ... -
Regulation of amyloid beta generation and its involvement in synaptic function: studies in human iPSC-derived cortical neurons
(2024-02-21)Alzheimer’s disease (AD) is a neurodegenerative disease that affects millions of individuals worldwide and exerts a profound societal and economic impact. Clinically characterized by a gradual loss of memory, cognitive and ... -
Labile glutamate synaptic transmission onto CA1 hippocampal pyramidal neurons: regional, functional and developmental diversity
(2024-02-14)A single neuron in the brain receives tens of thousands of glutamate synapses from other neurons, and these synapses can differ in their properties depending on their role in the neural circuit, during brain development ... -
Outcome after treatment of cerebral aneurysms
(2024-02-08)A cerebral aneurysm is a saccular or tubular-like deformity of the arterial vessel wall which is usually thinner. The rupture of a cerebral aneurysm is associated with a high morbidity and mortality by causing an aneurysmal ... -
Speech production and literacy in students with intellectual disabilities and communication difficulties
(2024-02-07)Many individuals with intellectual disabilities have difficulties with spoken communication and literacy learning leading to vulnerability. It has been suggested that interventions to promote reading in this group not only ... -
Pregnancy-related pelvic girdle pain management. Tailored physiotherapy treatment strategies anchored in women's experiences and expectations
(2024-01-11)Introduction: Pregnancy-related pelvic pain (PGP) affects over half of all pregnant women. This pain can significantly impact daily activities and limit the ability to move freely, leading to reduced physical activity, ... -
Children who screen positive for language delay but not autism: from 2.5 to 6 years of age
(2023-12-05)Background: Language disorders (LDs) are prevalent, affecting approximately 10% of children. Among them, 7.5% have developmental language disorder (DLD), while 2.5% have LD associated with a known medical condition. In ... -
The AfterBabyBodyStudy: Muscular changes, exercising, and activity limitations and their associations with pelvic girdle pain and urinary incontinence in the postpartum period
(2023-11-21)Aim: Pregnancy and childbirth can lead to several symptoms, changes in the pelvic floor muscles and a diastasis recti abdominis (DRA). This thesis aimed to assess and explore stress urinary incontinence, vaginal heaviness, ... -
Sex differences in behavior and metabolism
(2023-11-16)Men and women exhibit distinct illness patterns and disparate responses to pharmacotherapies. However, there is a scarcity of preclinical studies that systematically compare the sexes. The overarching aim of this thesis ... -
Physical activity and stroke - Associations and patient experiences
(2023-11-15)Background: Insufficient physical activity is a global problem and a risk factor for stroke. Furthermore, physical activity is often reduced after stroke, and many patients are physically inactive in stroke units. Aim: ... -
Pharmacokinetics and pharmacodynamics of the psychedelic compound DMT
(2023-11-15)N,N-dimethyltryptamine (DMT) is a psychedelic compound that is being investigated as a treatment option in depression. It is also being used as a research tool in research aiming to investigate the neurobiology of the ... -
Young Children with Autism in a Multiethnic Immigrant Population. Prevalence, Feeding Disorders, Early Detection, and Intervention
(2023-11-14)Background: Autism is a neurodevelopmental condition characterized by a pattern of major impairments in social communication and behavioural/sensory problems, with high rates of coexisting neurodevelopmental and medical ... -
On the Surgical Management of Diffuse Low-Grade Gliomas in Adults
(2023-11-10)Diffuse low-grade gliomas (dLGG) are rare, slow-growing, yet difficult-to-treat brain tumors that typically affect young to middle-aged adults. The aim of the thesis has been to identify factors affecting management and ...