Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi
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Guillian-Barré syndrome: Epidemiology and biomarkers in blood and cerebrospinal fluid
(2025-04-15)Guillain-Barré syndrome (GBS) is a rare, potentially life-threatening disease. The incidence of GBS varies, and clusters can occur related to the increased prevalence of triggering events. Most patients recover well, but ... -
Functioning after COVID-19 – A long term follow-up of hospitalized patients using qualitative and quantitave methods
(2025-04-09)ABSTRACT Background: In 2020, the novel SARS-CoV-2 virus triggered the COVID-19 pandemic, overwhelming healthcare systems worldwide and causing significant suffering. At the time, the long-term consequences of COVID-19 ... -
Sex-specific modulation of neurobehavioral outcomes - The intersection of sex steroids, gut peptides, and behavior
(2025-04-09)Despite ample evidence indicating that psychiatric disorders and their symptoms exhibit significant differences based on sex, research on their underlying mechanisms in females has historically been limited. This thesis ... -
Post-traumatic epilepsy: Risk factors, Clinical insights, Socioecinomic aspects and prognosis
(2025-04-03)Traumatic brain injury (TBI) is a common cause of acquired epilepsy, and the risk of post-traumatic epilepsy (PTE) increases with the severity of the TBI. The risk of PTE varies in the literature, and following a post-traumatic ... -
Epidemiology of Humanpapilloma Virus in East Africa
(2025-03-28)ABSTRACT Background: Human papillomavirus (HPV) infection is a well-known etiological factor in cervical, anogenital, and head and neck malignancies. East Africa has the highest global prevalence of HPV infections and the ... -
Long-term Mental Health and Multimorbidity Outcomes in 22q11.2 deletion syndrome - A Comprehensive Study from Childhood to Adulthood
(2025-03-17)22q11.2 deletion syndrome (22q11.2DS) is a genetic disorder with a markedly diverse phenotype. Aims: Examine mental health and multimorbidity in adults with 22q11.2DS followed prospectively from childhood/young adult age ... -
Health improvement in chronic widespread pain. Outcomes and experiences
(2025-03-04)Aim: The purpose of this thesis was to investigate changes in health outcomes and experiences of improvement over time and the effect of person-centred physical activity delivered with digital e-health support on health ... -
Gut-brain peptides and drugs of abuse: highlighting the role of GLP-1 and amylin
(2025-02-27)Alcohol use disorder (AUD) and cocaine use disorder (CUD) are complex conditions with diverse neurobiological foundations. Current treatments for AUD and CUD are suboptimal; gaining a deeper understanding of the underlying ... -
Taming the masses: Proteomic profiling across the spectrum and stages of neurodegenerative diseases
(2025-02-25)Neurodegenerative diseases (NDs) are a group of brain-related disorders that mainly affect individuals of older age. They are characterized by a progressive loss of neurons, which ultimately results in a wide array of ... -
Early mobilization in intensive care Experiences of patients and healthcare professionals, and a comparison of physiological responses during mobilization
(2025-01-30)Introduction. Early mobilization in intensive care is frequently used to prevent physical and psychological complications, with promising results. As its significance becomes increasingly apparent, understanding the ... -
Evaluating Virtual Reality and Artificial lntelligence as Emerging Digital Tools for Mental Health Care
(2025-01-16)This thesis evaluates the potential of Virtual Reality (VR) and Artificial Intelligence (AI), specifically Natural Language Processing (NLP) and Large Language Models (LLMs), as emerging tools for mental health care. VR ... -
Drug interactions in healthcare - Knowledge resources and clinical management
(2025-01-14)Background and aim: Many patients are treated with several drugs concomitantly, implying a risk of drug interactions. The clinical consequences of drug interactions depend not only on the drugs, but also on patient ... -
Gravitostat: A Homeostatic Regulator of Body Weight
(2025-01-14)This project focuses on elucidating central and peripheral physiological mechanisms behind load-induced body weight reduction. These pre-clinical works are a continuation of previous studies in obese humans and Diet-Induced ... -
Advancements in the Neuropsychology of Alzheimer's Disease
(2025-01-08)Background: In Alzheimer's disease (AD), the buildup of amyloid-β and hyperphosphorylated tau protein in the brain starts years before clinical symptoms appear. This process then progresses in parallel with cognitive ... -
The role of taurine-related compounds on the effects of ethanol in the rat mesolimbic dopamine system
(2025-01-08)Alcohol use disorder (AUD) is a major contributor to the global burden of disease. The reinforcing properties of alcohol involve enhanced dopamine activity in the nucleus accumbens (nAc), an important part of the mesolimbic ... -
Correlative Chemical Imaging of Amyloid Plaque Pathology in Alzheimer’s Disease
(2024-12-11)The formation of beta-amyloid (Aβ) plaques and neurofibrillary tangles are key pathological hall-marks of Alzheimer’s disease (AD), where amyloid has been identified to precede and even initiate other neurodegenerative ... -
Nanoelectrochemical analysis of neurotransmitter release in cell models of Alzheimer's disease
(2024-12-04)Neurotransmitter release and binding to receptors are tightly regulated, and aberrant changes can cause neuropsychiatric and neurodegenerative disorders. Alzheimer's disease (AD) is a complex, age-related neurodegenerative ... -
Diagnostic imaging and functional outcome in patients with diffuse glioma grades 2 and 3. From presentation to the 12-month post-operative follow-up
(2024-12-04)The overall aim of this thesis was to contribute to the improvement of diagnostic imaging and functional outcome practices in adult patients with diffuse glioma grades 2 or 3. At the preoperative stage our studies assessed ... -
Team-based rehabilitation in primary care for patients with musculoskeletal disorders Experiences, effect- and process evaluation
(2024-11-20)Most people will experience musculoskeletal disorders at some point in their lives, ranging from a manageable problem to significant difficulties with mobility, sleeping, performing daily activities, and working. There is ... -
Exploring pain, fatigue and physical activity in adolescents with Hypermobility Spectrum Disorder or hypermobile Ehlers-Danlos Syndrome
(2024-11-19)Adolescents with Hypermobility Spectrum Disorder (HSD) and hypermobile Ehlers–Danlos Syndrome (hEDS) — two overlapping hereditary connective-tissue disorders characterized by joint hypermobility, chronic pain, impaired ...
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