• Long-term Mental Health and Multimorbidity Outcomes in 22q11.2 deletion syndrome - A Comprehensive Study from Childhood to Adulthood 

  Wallin, Lena (2025-03-17)

  22q11.2 deletion syndrome (22q11.2DS) is a genetic disorder with a markedly diverse phenotype. Aims: Examine mental health and multimorbidity in adults with 22q11.2DS followed prospectively from childhood/young adult age ...

• Health improvement in chronic widespread pain. Outcomes and experiences 

  Sofia, Juhlin (2025-03-04)

  Aim: The purpose of this thesis was to investigate changes in health outcomes and experiences of improvement over time and the effect of person-centred physical activity delivered with digital e-health support on health ...

• Gut-brain peptides and drugs of abuse: highlighting the role of GLP-1 and amylin 

  Aranäs, Cajsa (2025-02-27)

  Alcohol use disorder (AUD) and cocaine use disorder (CUD) are complex conditions with diverse neurobiological foundations. Current treatments for AUD and CUD are suboptimal; gaining a deeper understanding of the underlying ...

• Taming the masses: Proteomic profiling across the spectrum and stages of neurodegenerative diseases 

  Weiner, Sophia (2025-02-25)

  Neurodegenerative diseases (NDs) are a group of brain-related disorders that mainly affect individuals of older age. They are characterized by a progressive loss of neurons, which ultimately results in a wide array of ...

• Early mobilization in intensive care Experiences of patients and healthcare professionals, and a comparison of physiological responses during mobilization 

  Söderberg, Annika (2025-01-30)

  Introduction. Early mobilization in intensive care is frequently used to prevent physical and psychological complications, with promising results. As its significance becomes increasingly apparent, understanding the ...

• Evaluating Virtual Reality and Artificial lntelligence as Emerging Digital Tools for Mental Health Care 

  Almira, Osmanovic Thunström (2025-01-16)

  This thesis evaluates the potential of Virtual Reality (VR) and Artificial Intelligence (AI), specifically Natural Language Processing (NLP) and Large Language Models (LLMs), as emerging tools for mental health care. VR ...

• Drug interactions in healthcare - Knowledge resources and clinical management 

  Tukukino, Carina (2025-01-14)

  Background and aim: Many patients are treated with several drugs concomitantly, implying a risk of drug interactions. The clinical consequences of drug interactions depend not only on the drugs, but also on patient ...

• Gravitostat: A Homeostatic Regulator of Body Weight 

  Zlatkovic, Jovana (2025-01-14)

  This project focuses on elucidating central and peripheral physiological mechanisms behind load-induced body weight reduction. These pre-clinical works are a continuation of previous studies in obese humans and Diet-Induced ...

• Advancements in the Neuropsychology of Alzheimer's Disease 

  Öhman, Fredrik (2025-01-08)

  Background: In Alzheimer's disease (AD), the buildup of amyloid-β and hyperphosphorylated tau protein in the brain starts years before clinical symptoms appear. This process then progresses in parallel with cognitive ...

• The role of taurine-related compounds on the effects of ethanol in the rat mesolimbic dopamine system 

  Ademar, Karin (2025-01-08)

  Alcohol use disorder (AUD) is a major contributor to the global burden of disease. The reinforcing properties of alcohol involve enhanced dopamine activity in the nucleus accumbens (nAc), an important part of the mesolimbic ...

• Correlative Chemical Imaging of Amyloid Plaque Pathology in Alzheimer’s Disease 

  Ge, Junyue (2024-12-11)

  The formation of beta-amyloid (Aβ) plaques and neurofibrillary tangles are key pathological hall-marks of Alzheimer’s disease (AD), where amyloid has been identified to precede and even initiate other neurodegenerative ...

• Nanoelectrochemical analysis of neurotransmitter release in cell models of Alzheimer's disease 

  Pradhan, Ajay (2024-12-04)

  Neurotransmitter release and binding to receptors are tightly regulated, and aberrant changes can cause neuropsychiatric and neurodegenerative disorders. Alzheimer's disease (AD) is a complex, age-related neurodegenerative ...

• Diagnostic imaging and functional outcome in patients with diffuse glioma grades 2 and 3. From presentation to the 12-month post-operative follow-up 

  Gómez Vecchio, Tomás Agustín (2024-12-04)

  The overall aim of this thesis was to contribute to the improvement of diagnostic imaging and functional outcome practices in adult patients with diffuse glioma grades 2 or 3. At the preoperative stage our studies assessed ...

• Team-based rehabilitation in primary care for patients with musculoskeletal disorders Experiences, effect- and process evaluation 

  Ekhammar, Annika (2024-11-20)

  Most people will experience musculoskeletal disorders at some point in their lives, ranging from a manageable problem to significant difficulties with mobility, sleeping, performing daily activities, and working. There is ...

• Exploring pain, fatigue and physical activity in adolescents with Hypermobility Spectrum Disorder or hypermobile Ehlers-Danlos Syndrome 

  Schubert Hjalmarsson, Elke (2024-11-19)

  Adolescents with Hypermobility Spectrum Disorder (HSD) and hypermobile Ehlers–Danlos Syndrome (hEDS) — two overlapping hereditary connective-tissue disorders characterized by joint hypermobility, chronic pain, impaired ...

• Novel biomarkers for parkinsonian disorders 

  Fernandes Gomes, Bárbara (2024-11-12)

  Parkinsonian disorders (PS) are a heterogeneous group of neurodegenerative diseases characterised by the presence of parkinsonism. Parkinson’s disease (PD) is the most common PS, characterised by the accumulation of ...

• Endocrine and neural mechanisms in metabolic control 

  Asker, Mohammed (2024-11-11)

  The regulation of eating behavior and metabolism is governed by complex inter-actions between central and peripheral signals, with hormones such as oxytocin (OT) and glucagon-like peptide-1 (GLP-1) playing pivotal roles. ...

• The alpha 7 nicotinic acetylcholine receptor in cardiovascular disease 

  Mjörnstedt Lyster, Filip (2024-09-26)

  The alpha 7 acetylcholine nicotinic receptors (α7nAChRs) are expressed on human leukocytes and regulate inflammation. Consequently, the α7nAChRs are potential pharmacological targets for several inflammatory diseases. ...

• Social and motor coordination: methods development and applications in ESSENCE 

  Thorsson, Max (2024-09-24)

  This thesis aimed to develop and apply methods for evaluating social and motor coordination, domains that often are challenged in individuals with neurodevelopmental/neuropsychiatric disorders (NDDs), also referred within ...

• Survival of patients with glioblastoma - advancements in the past two decades 

  Fekete, Boglarka (2024-09-24)

  Background: Glioblastoma is the most common and most aggressive form of primary malignant brain tumors in adults. The prognosis is generally poor, with a median survival of around 15-16 months, even with aggressive multimodal ...

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