Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi
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The AfterBabyBodyStudy: Muscular changes, exercising, and activity limitations and their associations with pelvic girdle pain and urinary incontinence in the postpartum period
(2023-11-21)Aim: Pregnancy and childbirth can lead to several symptoms, changes in the pelvic floor muscles and a diastasis recti abdominis (DRA). This thesis aimed to assess and explore stress urinary incontinence, vaginal heaviness, ... -
Sex differences in behavior and metabolism
(2023-11-16)Men and women exhibit distinct illness patterns and disparate responses to pharmacotherapies. However, there is a scarcity of preclinical studies that systematically compare the sexes. The overarching aim of this thesis ... -
Physical activity and stroke - Associations and patient experiences
(2023-11-15)Background: Insufficient physical activity is a global problem and a risk factor for stroke. Furthermore, physical activity is often reduced after stroke, and many patients are physically inactive in stroke units. Aim: ... -
Pharmacokinetics and pharmacodynamics of the psychedelic compound DMT
(2023-11-15)N,N-dimethyltryptamine (DMT) is a psychedelic compound that is being investigated as a treatment option in depression. It is also being used as a research tool in research aiming to investigate the neurobiology of the ... -
Young Children with Autism in a Multiethnic Immigrant Population. Prevalence, Feeding Disorders, Early Detection, and Intervention
(2023-11-14)Background: Autism is a neurodevelopmental condition characterized by a pattern of major impairments in social communication and behavioural/sensory problems, with high rates of coexisting neurodevelopmental and medical ... -
On the Surgical Management of Diffuse Low-Grade Gliomas in Adults
(2023-11-10)Diffuse low-grade gliomas (dLGG) are rare, slow-growing, yet difficult-to-treat brain tumors that typically affect young to middle-aged adults. The aim of the thesis has been to identify factors affecting management and ... -
Physiology and Pathophysiology of Hormone Secretion from lslets of Langerhans
(2023-10-30)Diabetes is a metabolic disorder stemming from the improper regulation of blood glucose levels by hormones secreted by pancreatic islets of Langerhans. Paper I describes the mechanism by which glucose can regulate glucagon ... -
Executive functions and ERP Biomarkers in children and adolescents with ADHD and Autism
(2023-10-19)Executive Functions (EF) refers to skills that help us initiate, organize and evaluate activities. Problems with EF are associated with neurodevelopmental disorders such as Attention Deficit Hyperactivity Disorder (ADHD) ... -
Hearing in advanced age Epidemiological, pathophysiological, and diagnostic perspectives from the Gothenburg H70 Birth Cohort Studies
(2023-10-16)The population aged 80 and above is expected to increase in the future resulting in an anticipated rise in health care demands. Age-related hearing loss (ARHL) is described as the third most common health condition ... -
Amyloid Maturation Patterns in Alzheimer's Disease - Novel chemical imaging of Aβ and Tau pathology
(2023-10-11)Alzheimer’s disease (AD) accounts for approximately 70% of dementia cases in Sweden. It can be of genetic origin i.e. familial form (fAD), sporadic form (sAD). AD is characterized by the deposition of amyloid and tau ... -
Upper extremity functioning in individuals with cervical or thoracic spinal cord injury - From body functions to participation
(2023-09-28)Background: A spinal cord injury (SCI) can lead to a range of impairments in various body functions, including the function of upper extremity, with severity varying from mild to severe. Long-term consequences for functioning ... -
Suicidality and depression in older adults: Prevalence, predictors, and outcomes
(2023-09-08)Older adults have the highest risk of suicide of all age groups. Depression is a major risk factor for suicide in late life, but is also associated with lower quality of life, somatic disorders, and premature death. The ... -
Gambling, alcohol and gender: Subjective effects and clinical characteristics
(2023-09-01)Gambling and alcohol are two recreational activities enjoyed by many people all over the world. Most with the purpose of leisure and social interaction with little or no consequence to impact daily life. For some however ... -
The relationship between cognition and ESSENCE in childhood
(2023-08-29)Aims: To examine the relationship between cognition and ESSENCE (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations) features in children, ages 7-8 years. To investigate the importance of ... -
Pre/Peri/Earl-Life Exposures and Early Child Neurodevelopment: Results from the Japan Environment and Children's Study (JECS)
(2023-08-18)Background: Combinations of genetic and environmental factors contribute to aetiologies of neuropsychiatric problems and neurodevelopmental disorders (NDDs) in intricate manners. Among the environmental factors, exposures ... -
Oropharyngeal dysphagia in adults: Prevalence, professional practices, patient perspectives and treatment outcomes
(2023-05-25)Background: Oropharyngeal dysphagia (OD) is defined as any disruption in the transportation of food/liquids safely and efficiently from the mouth, through the pharynx and into the esophagus. The underlying causes of OD ... -
Machine learning and big data for personalized epilepsy treatment
(2023-05-23)Finding an effective anti-seizure medication (ASM) with minimal side effects is a challenge. Patient characteristics are used to guide treatment selection, but about half of the patients with epilepsy do not achieve seizure ... -
Cardiometabolic risk indicators in bipolar disorders
(2023-05-15)In addition to disabling mood episodes, bipolar disorders (BDs) predispose individuals to high cardiovascular disease (CVD) risk. This thesis explores the association between BDs and the metabolic risk indicators body mass ... -
Quality of drug treatment in older people from a medical primary care perspective and according to indicators
(2023-05-09)Background: Drug treatment in older people is particularly complex; the burden of disease increases by age, and patients in this age group are more sensitive to drug effects. As a knowledge resource for clinicians as well ... -
Seizure and non-seizure outcomes after epilepsy surgery in selected patient groups
(2023-05-09)This thesis addresses some understudied aspects of epilepsy surgery with special emphasis on children and adolescents. The specific aims were to analyse educational and employment outcomes after epilepsy surgery in ...