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Novel cerebrospinal fluid and blood tau biomarkers in Alzheimer's disease and other neurodegenerative diseases
(2022-03-18)
Tau is a protein predominantly expressed in neurons in the central nervous system (CNS), where it binds microtubules (MT), playing a major role regulating their dynamics and architecture. Under pathological conditions, tau ...
On cataract surgery in uveitis - management and outcome in pediatric and adult patients
(2022-04-06)
Aims: To evaluate surgical procedures and outcomes in cataract surgery in adults and
children with uveitis. To compare the results of implantation of two different
intraocular lenses (IOLs).
Methods: Retrospective reviews ...
Pre/Peri/Earl-Life Exposures and Early Child Neurodevelopment: Results from the Japan Environment and Children's Study (JECS)
(2023-08-18)
Background: Combinations of genetic and environmental factors contribute to aetiologies of neuropsychiatric problems and neurodevelopmental disorders (NDDs) in intricate manners. Among the environmental factors, exposures ...
Cerebrospinal fluid studies of bipolar disorder
(2022-04-14)
The pathophysiology of bipolar disorder remains to be elucidated. One approach to studying brain processes is analysis of cerebrospinal fluid (CSF). This thesis comprises five studies based on the Sankt Göran Bipolar Project ...
Stretch-shortening cycle (SSC) muscle power, muscle strength and functional capacity in Scandinavian women and men - Effects of ageing
(2022-04-07)
Ageing is associated with a gradual decline in physical function due to age-related loss of muscle mass, strength, and muscle power, leading to loss of independence. Physical therapists employ various tests to assess of ...
The neuromodulatory effect of extracellular ions in the central nervous system
(2022-08-23)
Neurons are the cells that send and receive signals in the central nervous system. Neuronal signaling is the base for all the complex tasks the human brain is capable of, from the detection of a smell to the composition ...
Acute pulmonary embolism - aspects of respiratory symptoms and physical activity
(2022-03-16)
Introduction. Pulmonary embolism (PE) is the third most common cardiovascular disease, after myocardial infarction and stroke. Post-PE syndrome, which is characterized by long-term consequences of PE with persistent dyspnea ...
Investigations into the role of Epstein-Barr virus in the pathogenesis of multiple sclerosis
(2022-09-08)
Epstein-Barr virus (EBV) infection may be a prerequisite for the development of MS.
Virtually all MS patients have antibodies to Epstein Barr virus nuclear antigen 1
(EBNA1), compared to 90-95% of healthy individuals. ...
Oral eflornithine treatment of late-stage human African trypanosomiasis
(2022-11-21)
Human African trypanosomiasis is a fatal disease unless treated. It is a parasitic vector borne disease endemic in sub-Saharan African countries. Eflornithine is a recommended treatment for gambiense human African ...
DNA methylation profiling of CNS tumors; implications for clinical diagnostics
(2022-10-05)
Diffuse gliomas and meningiomas are the most common primary tumors of the central nervous system (CNS) in adults and these
tumors cause significant morbidity and mortality worldwide. Deregulation of the epigenetic mechanisms, ...