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Radiological and Clinical Changes in Idiopathic Normal Pressure Hydrocephalus: MRI, Vascular factors and Clinical Symptoms as Markers of Pathophysiology and Prognosis
(2020-01-15)
Idiopathic normal pressure hydrocephalus (iNPH) is a treatable, neurological disorder affecting the elderly population causing gait, balance, cognitive and micturition impairments. Treatment results in a clinical improvement ...
Cerebrospinal fluid biomarkers and cognition in older adults
(2021-04-21)
Alzheimer’s disease (AD) is the most common type of dementia. The cause of the disease is unknown, but a substantial amount of evidence suggest that the disease is started by an imbalance in the production and clearance ...
Enriched, task specific therapy in the chronic phase after stroke
(2021-03-29)
Recovery and improvement of motor functions and abilities after stroke depend on the spontaneous recovery process but also on the reorganization of neural mechanisms. In animal studies, an Enriched Environment (EE) has ...
Fluid biomarkers of extracellular matrix remodelling across neurological diseases
(2021-02-12)
Neurological diseases constitute a major health and socioeconomic issue. Despite an enormous amount of research going on globally, the prevalence and mortality of neurological disorders are still rising. This has placed a ...
On the efficacy and prescription of serotonin reuptake inhibitors
(2021-09-09)
This thesis addresses several controversial issues regarding commonly used antidepressants, including selective serotonin reuptake inhibitors (SSRIs), serotonin and noradrenaline reuptake inhibitors (SNRIs), and tricyclic ...
Word-finding difficulties in left hemisphere stroke, multiple sclerosis and Parkinson's disease - differences in symptom occurrence and effects of anomia treatment
(2021-11-11)
Word-finding difficulties, or anomia, are a common symptom in various conditions affecting the brain, such as stroke, multiple sclerosis (MS) or Parkinson’s disease (PD). The aim of this thesis is twofold: (i) to increase ...
A Podocyte view on RhoGTPases and actin cytoskeleton regulation
(2020-06-11)
Proteinuria is a hallmark symptom of chronic kidney disease, that if left to persist constitutes a risk for progression of disease. Symptomatic treatment aiming at decreasing proteinuria is therefore standard practice. ...
Occupational engagement after stroke - a long-term perspective
(2020-09-03)
Introduction: In the literature it is recognized that stroke can have lifelong consequences and that these consequences become evident in the occupations that constitute everyday life. With an increase in prevalence and ...
On Aging, Behavior and the Role of PA28αβ in Protein Homeostasis
(2020-04-23)
As life expectancy increases, understanding challenges related to the processes of aging are more relevant than ever. Common age-related diseases progress as consequences of accumulative protein damage and protein aggregates. ...
lnternalizing problems in childhood and adolescence: predictive, etiological, and neurodevelopmental aspects
(2021-11-25)
Internalizing disorders such as anxiety and depressive disorders are common mental
disorders in childhood and adolescence. They are characterized by disordered
emotions and moods, causing emotional distress and impairment. ...