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Lithium protects the juvenile brain from ionizing radiation
(2015-10-14)
Radiotherapy used in the treatment of brain tumours in children results in a range of cognitive dysfunctions that impact the quality of life in the surviving population. In past decades, great strides were made in understanding ...
From mice to men - astrocytes and neural progenitor cells in neural plasticity and regeneration
(2017-02-06)
Astrocytes, a key homeostatic cell type in the mammalian central nervous system (CNS), have various functions in health and diseases. In neurotrauma, stroke, epilepsy or neurodegenerative diseases, astrocytes become reactive, ...
The role of the complement system in ischemic stroke and neural plasticity
(2013-10-29)
Evidence from experimental animal studies suggests that complement activation in the brain is a “double-edged sword” as it exerts beneficial or detrimental effects depending on the context. Here, we assessed whether ...
Behavior and cytogenesis following irradiation or isoflurane exposure to the developing brain
(2010-08-30)
In this thesis, the effects of an anesthetic agent, isoflurane, on the young brain and resulting behavioral effects were investigated. Anesthesia is commonly used in young children during surgery or other procedures ...
The role of astrocytes in stroke, brain plasticity and neurogenesis
(2013-05-10)
Astrocytes, one of the most abundant and heterogeneous cell types in the central nervous system, fulfill many important roles in the healthy and injured brain. This thesis investigates the role of astrocytes in the neurogenic ...
Irradiation-induced injury to the juvenile brain -Roles of sex and inflammation
(2013-11-14)
Radiotherapy is commonly used in the treatment of pediatric malignancies, but unfortunately it is associated with negative side effects, both long-term and short-term. Negative side effects following cranial irradiation ...