Infection/inflammation and/or hypoxia-ischemia (HI) are major causes of perinatal brain injury. Toll-like receptors (TLRs), important components of innate immunity, have been shown to be involved in brain injury, both after ...

Perinatal brain injury is an important cause of mortality and morbidity and is associated with neurological disabilities such as those seen in cerebral palsy. Prematurity, especially in combination with very low birth ...

Inflammation plays an important role in cerebral ischemic injury in the immature brain. The aim of the thesis was to investigate (1) the role of astrocyte activation and reactive gliosis in neonatal hypoxic-ischemic (HI) ...