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Inflammation in the immature brain: The role of Toll like receptors
(2011-10-28)
Infection/inflammation and/or hypoxia-ischemia (HI) are major causes of perinatal brain injury. Toll-like receptors (TLRs), important components of innate immunity, have been shown to be involved in brain injury, both after ...
Developing brain and systemic inflammation: a "Toll-like" link with consequences
(2017-05-24)
The developing brain is vulnerable to external insults, and perinatal brain injury (PBI) is a major cause of life-long neurological syndromes such as cerebral palsy. Currently, no pharmaceutical intervention is available. ...
Genetics of Parkinson's disease - with focus on genes of relevance for inflammation and dopamine neruon development
(2010-02-18)
Abstract
GENETICS OF PARKINSON’S DISEASE
- WITH FOCUS ON GENES OF RELEVANCE FOR INFLAMMATION AND DOPAMINE NEURON DEVELOPMENT
Introduction: The risk to be affected by Parkinson’s disease (PD) is considered to be ...
The role of neonatal immunity in preterm brain injury
(2016-11-23)
Perinatal brain injury is an important cause of mortality and morbidity and is associated with neurological disabilities such as those seen in cerebral palsy. Prematurity, especially in combination with very low birth ...
The Role of the Autonomic Nervous System in Atherosclerosis - Targeting the Cholinergic Anti-inflammatory Pathway in Humans and Mice
(2017-01-20)
The autonomic nervous system (ANS) has been implicated in numerous atherosclerosis-induced cardiovascular disease, such as myocardial infarction and stroke. Although evidence suggests a relationship between autonomic ...
On the importance of inflammation for personality traits and psychiatric morbidity
(2010-12-10)
Background: Pro-inflammatory mediators have been implicated in processes that could be both beneficial and toxic to cells in the brain. On the one hand balanced levels of these mediators favour e.g. neurodevelopmental ...
Muscarinic receptors in the urinary bladder - The role of the urothelium regarding cholinergic and nitrergic effects in inflammation
(2010-11-19)
Inflammation alters the functional properties of the urinary bladder. Interstitial cystitis (IC) is a chronic inflammatory syndrome in man that is characterized by urgency, frequency and visceral pain. The overall aim of ...
Inflammation and Cell Profileration Following Perinatal Brain Injury
(2010-08-30)
Inflammation plays an important role in cerebral ischemic injury in the immature brain. The aim of the thesis was to investigate (1) the role of astrocyte activation and reactive gliosis in neonatal hypoxic-ischemic (HI) ...
Biomarkers in Multiple Sclerosis - Monitoring disease activity and treatment afficacy
(2018-03-21)
The pathophysiology of multiple sclerosis (MS) is complex with the presence of inflammation and neurodegeneration in all stages of the disease. The disease course, treatment response and outcome are highly variable in MS. ...
Neurobiological markers for personality, inflammation and stress: A naturalistic study in knee arthroplastic patients
(2013-03-25)
Background: Psychiatry has strived to identify biomarkers elucidating the underlying biological mechanisms behind different disorders, to help in diagnostics and to assess treatment effects. In forensic psychiatric ...