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Proteomic strategies for analysis of cerebrospinal fluid in neurodegenerative disorders
(2008-04-04)
ABSTRACT
There is a great need for biomarkers to diagnose neurodegenerative disorders, such as the cognitive disorders Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Cerebrospinal fluid (CSF) is in contact ...
Targeted Abeta proteomics - A tool to study the pathogenesis of Alzheimer's disease
(2009-09-04)
Alzheimer’s disease (AD) is an age-related progressive neurodegenerative disorder of the central nervous system. Diagnosis and monitoring of sporadic AD has long depended on clinical examination of individuals with end-stage ...
Susceptibility genes in conformational diseases
(2009-12-04)
Conformational diseases are characterized by protein misfolding and aggregation in the affected tissue. The aim of this thesis was to find genetic support for mechanisms in common for three prevalent confor-mational diseases: ...