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Psychological stress in relation to dementia and brain structural changes
(2012-09-03)
Psychological stress has been recognized as an increasing public health problem with serious consequences in both physical and mental health. Women reported a higher prevalence of psychological stress, especially in midlife. ...
CSF biomarkers reflecting beta-amyloid and axonal pathology in Alzheimer's disease and related conditions
(2011-11-18)
Cerebrospinal fluid (CSF) biomarkers may be used to identify and monitor pathological processes in the central nervous system. CSF biomarkers in Alzheimer’s disease (AD) include β-amyloid 42 (Aβ42), total-tau (T-tau) and ...
Mild Cognitive Impairment - concepts, cut-offs, and clinical relevance
(2019-04-25)
Mild cognitive impairment (MCI) is a diagnosis frequently used in dementia research and in memory clinics. MCI is meant to identify patients without dementia, but with cognitive decline beyond what is considered normal, ...
Tau fragments: role as biomarkers and in the pathogenesis of Alzheimer's disease and other tauopathies
(2019-09-10)
Abstract
Tau protein is physiologically expressed in neurons, where it is involved in microtubule assembly and stability. Tau functions are rigorously regulated by a series of modifications, e.g. phosphorylation and ...
Cerebrospinal fluid peptidomics: discovery of endogenous peptides as biomarkers of Alzheimer's disease
(2018-10-02)
Neurodegenerative diseases (NDs), the most prominent example of which is Alzheimer’s disease (AD), has turned out to be among the greatest challenges for modern medicine. Common characteristics of NDs involve the aggregation ...
The postsynaptic protein neurogranin: a new item in the Alzheimer’s disease biomarker toolbox
(2019-03-13)
Alzheimer’s disease (AD) is the most common form of dementia affecting more than 50 million people worldwide today and is characterised by progressive cognitive decline. One of the earliest events in AD, which is also ...
Hippocampal volumetry in mild cognitive impairment
(2010-09-10)
Dementia is a syndrome with cognitive decline as a prominent feature. MCI is similarly a syndrome of cognitive decline, albeit with much subtler symptoms, and has been identified as a condition at risk for progression to ...
Cerebrospinal fluid biomarkers for differentiating between Alzheimer’s disease and Vascular dementia
(2011-05-27)
Patients suffering from mild cognitive impairment (MCI) run a higher risk of developing dementia, with Alzheimer’s disease (AD) being the most common form. Vascular dementia (VaD) is proposed to be the second most common ...
The role of microglia in Alzheimer's disease - Investigating mechansims regulating amyloid-β clearance
(2016-05-31)
Alzheimer’s disease (AD) is the most common form of dementia today. The disease is characterized by the presence of amyloid plaques and neurofibrillary tangles in the brain, accompanied by a progressive neurodegeneration ...
Subjective cognitive decline in memory clinic patients - characteristics and clinical relevance
(2017-05-12)
Subjective cognitive decline (SCD) refers to concerns – symptoms - regarding one’s
cognitive functioning, in the absence of objective evidence of impairment. SCD has
been described as a possible stage preceding mild ...