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Preclinical investigations of GlyT-1 inhibition as a new concept for treatment of alcohol dependence
(2011-02-02)
Alcohol addiction and abuse is a main contributor to the global burden of disease and is a high public health priority. Alcohol addiction is a chronically relapsing neurobiological disorder affecting multiple neurotransmitter ...
The cholinergic-dopaminergic reward link and addictive behaviours: special emphasis on ethanol and ghrelin
(2007-05-16)
An important part of the reward systems is the cholinergic-dopaminergic reward link. This reward link has been proposed to be involved in reward and motivated behaviours. It encompasses a cholinergic input from the ...
Acute and chronic effects by stimulants on behavior and striatal neurotransmission in the rat
(2017-08-18)
Nicotine and amphetamines are the most widely abused stimulants. The main aim of the studies in this thesis was to investigate how these two drugs of abuse affect distinct regions of the rat brain involved in development ...
Glycine receptors in the central nervous system - development, distribution and relation to actions of alcohol
(2012-11-14)
The widespread consumption of alcohol and the great socioeconomic impact of alcohol abuse and addiction have contributed to the extensive investigations of this substance. Despite great efforts there is still uncertainty ...
Conditional and non-conditional reward-related responses to alcohol - nicotinic mechanisms
(2006-11-14)
The mesolimbic dopamine system is believed to mediate the positive reinforcing and rewarding effects of addictive drugs by increasing dopamine levels in its terminal area, the nucleus accumbens (nAc). Nicotinic acetylcholine ...
Cytochrome P450 2E1 - relevance for central dopamine neurotransmission and Parkinson's disease
(2008-08-25)
Introduction: The enzyme cytochrome P450 2E1 (CYP2E1) has been found in dopamine (DA) containing brain regions that are of relevance for Parkinson’s disease (PD), and is known to generate reactive oxygen species (ROS), ...
Dopamine and the regulation of movements - significance of nigral and striatal dopamine release in normal, hemiparkinsonian and dyskinetic rats
(2009-02-02)
Introduction: The nigrostriatal dopamine (DA) containing neurones are a pivotal component in the basal ganglia, a network that regulates movement. Degeneration of these neurones causes the cardinal symptoms of Parkinson’s ...
On the influence of dopamine-related genetic variation on dopamine-related disorders
(2009-11-13)
Rationale: Dopamine synthesizing neurons are involved in a wide variety of functions. The most prominent dopamine pathways originate in the midbrain. The development, function and survival of these dopaminergic neurons are ...
Ethanol-induced modulation of dopamine transmission and synaptic activity in striatal subregions - focus on inhibitory receptors
(2015-04-17)
Background: Alcoholism is a chronic brain disease, affecting neurocircuitries involved in reward and learning. The rewarding effects of alcohol (ethanol) are believed to result from increased dopamine levels in the nucleus ...
Dopaminergic lnterference for Treatment of Schizophrenia and Alcohol Use Disorder - an experimental study in rats
(2022-05-27)
The neurotransmitter dopamine is involved in several different physiological functions as well as pathological conditions. Two conditions that have been suggested to be related to a low dopaminergic tone in the ventral ...