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CSF biomarkers reflecting beta-amyloid and axonal pathology in Alzheimer's disease and related conditions
(2011-11-18)
Cerebrospinal fluid (CSF) biomarkers may be used to identify and monitor pathological processes in the central nervous system. CSF biomarkers in Alzheimer’s disease (AD) include β-amyloid 42 (Aβ42), total-tau (T-tau) and ...
Neurofilaments as biomarkers of neuronal damage
(2019-09-24)
Different neurodegenerative diseases have overlapping symptomatology and pathology and have thus become a challenge to modern medicine to achieve a correct diagnosis. The aim of the thesis was to evaluate the use of ...
The postsynaptic protein neurogranin: a new item in the Alzheimer’s disease biomarker toolbox
(2019-03-13)
Alzheimer’s disease (AD) is the most common form of dementia affecting more than 50 million people worldwide today and is characterised by progressive cognitive decline. One of the earliest events in AD, which is also ...
Increasing the interpretability of Alzheimer-related biomarkers: cell- and cerebrospinal fluid-based studies with focus on neurogranin
(2019-05-07)
Biomarkers for Alzheimer’s disease (AD) is a growing field of research. A particularly vibrant field during recent years has been biomarkers for synaptic dysfunction. Sensitive assays for a synaptic protein called neurogranin ...
The role of microglia in Alzheimer's disease - Investigating mechansims regulating amyloid-β clearance
(2016-05-31)
Alzheimer’s disease (AD) is the most common form of dementia today. The disease is characterized by the presence of amyloid plaques and neurofibrillary tangles in the brain, accompanied by a progressive neurodegeneration ...
Investigation of the pathophysiology of progression in multiple sclerosis: studies on cerebrospinal fluid biomarkers
(2013-04-23)
Multiple Sclerosis (MS) is considered an autoimmune disease of the central nervous system (CNS). It usually starts with a relapsing remitting (RR) course that eventually transforms into progressive (P)MS, showing ...