Search
Now showing items 1-5 of 5
Cognitive dysfunction studied in animal models of schizophrenia
(2006-12-01)
Cognitive dysfunction is considered a core deficit of schizophrenia, which currently lacks effective pharmacological treatment. In order to identify novel and more effective drug treatments, translational experimental ...
Cognition and social behaviour in schizophrenia: An animal model investigating the potential role of nitric oxide
(2007-11-27)
Cognitive deficits are the single strongest predictor of functional outcome in patients with schizophrenia. Furthermore, these deficits are not satisfactorily alleviated by available antipsychotic treatment. Functional ...
The prefrontal cortex and information processing : nitric oxide signaling studied in an animal model of schizophrenia
(2008-11-28)
The prefrontal cortex has been extensively linked to several cognitive domains that are severely compromised in schizophrenia. It has therefore become a key region for studies on the disabling cognitive dysfunction commonly ...
Dopaminergic stabilizers for the treatment of schizophrenia. Rat studies focusing on negative symptoms and mechanisms of action
(2007-11-21)
Schizophrenia is a severe mental disorder manifested by positive, negative and cognitive symptoms. Current antipsychotic drugs have poor effects on negative and cognitive symptoms, thus necessitating the development of new ...
On the influence of dopamine-related genetic variation on dopamine-related disorders
(2009-11-13)
Rationale: Dopamine synthesizing neurons are involved in a wide variety of functions. The most prominent dopamine pathways originate in the midbrain. The development, function and survival of these dopaminergic neurons are ...