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The cholinergic-dopaminergic reward link and addictive behaviours: special emphasis on ethanol and ghrelin
(2007-05-16)
An important part of the reward systems is the cholinergic-dopaminergic reward link. This reward link has been proposed to be involved in reward and motivated behaviours. It encompasses a cholinergic input from the ...
Conditional and non-conditional reward-related responses to alcohol - nicotinic mechanisms
(2006-11-14)
The mesolimbic dopamine system is believed to mediate the positive reinforcing and rewarding effects of addictive drugs by increasing dopamine levels in its terminal area, the nucleus accumbens (nAc). Nicotinic acetylcholine ...
Cytochrome P450 2E1 - relevance for central dopamine neurotransmission and Parkinson's disease
(2008-08-25)
Introduction: The enzyme cytochrome P450 2E1 (CYP2E1) has been found in dopamine (DA) containing brain regions that are of relevance for Parkinson’s disease (PD), and is known to generate reactive oxygen species (ROS), ...
Dopamine and the regulation of movements - significance of nigral and striatal dopamine release in normal, hemiparkinsonian and dyskinetic rats
(2009-02-02)
Introduction: The nigrostriatal dopamine (DA) containing neurones are a pivotal component in the basal ganglia, a network that regulates movement. Degeneration of these neurones causes the cardinal symptoms of Parkinson’s ...
On the influence of dopamine-related genetic variation on dopamine-related disorders
(2009-11-13)
Rationale: Dopamine synthesizing neurons are involved in a wide variety of functions. The most prominent dopamine pathways originate in the midbrain. The development, function and survival of these dopaminergic neurons are ...