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Now showing items 1-10 of 17
Novel cerebrospinal fluid and blood tau biomarkers in Alzheimer's disease and other neurodegenerative diseases
(2022-03-18)
Tau is a protein predominantly expressed in neurons in the central nervous system (CNS), where it binds microtubules (MT), playing a major role regulating their dynamics and architecture. Under pathological conditions, tau ...
Taming the masses: Proteomic profiling across the spectrum and stages of neurodegenerative diseases
(2025-02-25)
Neurodegenerative diseases (NDs) are a group of brain-related disorders that mainly affect individuals of older age. They are characterized by a progressive loss of neurons, which ultimately results in a wide array of ...
Fluid biomarkers of extracellular matrix remodelling across neurological diseases
(2021-02-12)
Neurological diseases constitute a major health and socioeconomic issue. Despite an enormous amount of research going on globally, the prevalence and mortality of neurological disorders are still rising. This has placed a ...
Dietary patterns among older adults - With focus on dementia and related biomarkers
(2022-10-18)
Background and aim: Diet is a lifestyle factor that can influence healthy ageing and the risk of developing dementia. Studies investigating dietary patterns among older adults in relation to dementia, and dementia-related ...
Proteomic strategies for analysis of cerebrospinal fluid in neurodegenerative disorders
(2008-04-04)
ABSTRACT
There is a great need for biomarkers to diagnose neurodegenerative disorders, such as the cognitive disorders Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Cerebrospinal fluid (CSF) is in contact ...
Targeted Abeta proteomics - A tool to study the pathogenesis of Alzheimer's disease
(2009-09-04)
Alzheimer’s disease (AD) is an age-related progressive neurodegenerative disorder of the central nervous system. Diagnosis and monitoring of sporadic AD has long depended on clinical examination of individuals with end-stage ...
Increasing the interpretability of Alzheimer-related biomarkers: cell- and cerebrospinal fluid-based studies with focus on neurogranin
(2019-05-07)
Biomarkers for Alzheimer’s disease (AD) is a growing field of research. A particularly vibrant field during recent years has been biomarkers for synaptic dysfunction. Sensitive assays for a synaptic protein called neurogranin ...
The physiological processing of Alzheimer-associated amyloid beta precursor protein in human and animal-derived neuronal models
(2020-02-27)
Alzheimer’s disease (AD) is characterized by cognitive impairment due to the loss of structure and/or function of neurons, and amyloid plaques composed of aggregated-amyloid beta (Aβ) peptides, primarily species ending at ...
Biomarkers for Alzheimer's disease and the APOE polymorphism
(2019-04-18)
Alzheimer’s disease (AD) is the most common form of dementia and cerebrospinal fluid (CSF) biomarkers reflecting the core pathology of AD are now widely used for diagnosis making, in particular β-amyloid[1-42] (Aβ42) ...
Advancements in the Neuropsychology of Alzheimer's Disease
(2025-01-08)
Background: In Alzheimer's disease (AD), the buildup of amyloid-β and hyperphosphorylated
tau protein in the brain starts years before clinical symptoms appear. This process then progresses
in parallel with cognitive ...