Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi by Subject "Malaria"
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Pharmacokinetics of artemisinin derivatives in rats, healthy volunteers and patients
(2015-09-04)Malaria is still a major health problem, killing approximately 1,600 people each day. The most vulnerable patient groups are children under the age of five and pregnant women. Artemisinin-based combination therapy is ... -
Piperaquine and Metabolites - Bioanalysis and Pharmacokinetics
(2017-09-28)Antimalarial piperaquine (PQ) is currently used as a partner drug with dihydroartemisinin (DHA), exhibiting high cure rates (>95%) for P. falciparum. Despite its raising usage worldwide with DHA, PQ is synthetically developed ... -
Population Pharmacokinetic-Pharmacodynamic Modelling of Antimalarial Treatment
(2014-11-28)Malaria is one of the most important tropical diseases, with hundreds of millions of cases every year. The current recommended treatment is an artemisinin based combination therapy (ACT), which has shown good efficacy. ...